The control of antibody production by immunomodulatory molecules.

Arthritis and Rheumatism
P E Lipsky

Abstract

Regulation of human B cell responses is a complex process that involves the activities of a variety of cytokines. There are important differences between the regulation of human and murine B lymphocytes, especially with regard to the action of IL-2. In humans, IL-2 appears to play a central role in regulating B cell activation, proliferation, and differentiation, thereby facilitating the production of immunoglobulins of all isotypes. A wide array of additional cytokines can amplify antibody production, but none appears to be able to do this in the absence of IL-2; moreover, none appears to enhance the production of only a single isotype of immunoglobulin. Beyond the positive influences of cytokines on B cell responses, at least 2 cytokines, IL-4 and TGF beta, suppress B cell proliferation and differentiation. Inhibition by each of these cytokines can be overcome by specific cytokines that provide positive signals to B cells. Antibody production is thus regulated by a complex array of cytokines with complementary or opposing effects that may be exerted at different stages of B cell responsiveness. Whether specific subpopulations of B cells exhibit unique cytokine requirements for differentiation has not been clearly delineated, ...Continue Reading

References

Jan 1, 1987·Annual Review of Biochemistry·S PestkaC E Samuel
Jan 1, 1989·Advances in Immunology·C A Dinarello
Dec 1, 1988·Immunology Today·J A Langer, S Pestka
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S MitaK Takatsu
Jan 1, 1988·The Journal of Clinical Investigation·J H KehrlW C Greene
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y H ZhangJ Vilcek
Sep 1, 1988·Immunology Today·K Bottomly
Jun 1, 1987·The Journal of Experimental Medicine·T DefranceK Arai
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S A HudakM R Kehry
May 1, 1988·Immunology Today·G G Wong, S C Clark
Aug 1, 1986·Immunological Reviews·T TaniguchiG Yamada
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M TsudoT A Waldmann
Apr 3, 1987·Science·R R HardyT Kishimoto
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M S LoughnanG J Nossal
Feb 1, 1988·Immunology Today·A O'GarraJ Christiansen
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Jan 1, 1987·Annual Review of Immunology·W E Paul, J Ohara
Dec 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W E Paul
Aug 1, 1987·The Journal of Experimental Medicine·L S ParkD L Urdal
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·H D CampbellI G Young
Aug 1, 1986·The Journal of Clinical Investigation·M B Sporn, A B Roberts
Feb 12, 1987·The New England Journal of Medicine·B Beutler, A Cerami
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R NoelleE S Vitetta
Jan 1, 1987·Immunology Today·S K Dower, D L Urdal

❮ Previous
Next ❯

Citations

Jan 1, 1991·Journal of Clinical Immunology·M T Halpern
Nov 1, 1995·Baillière's Clinical Rheumatology·M J Elliott, R N Maini
May 15, 2001·Journal of Clinical Periodontology·P N PapapanouG Dahlén
Oct 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L RinkH Kirchner
Aug 12, 2010·Immunopharmacology and Immunotoxicology·Chia-Chi WangTong-Rong Jan
Jan 5, 2001·Expert Opinion on Investigational Drugs·S Brunelleschi
Sep 1, 1993·Leukemia Research·T G HayesD P Huston
Aug 1, 1997·Rheumatic Diseases Clinics of North America·J T Cassidy, L S Hillman
Apr 25, 2008·Current Protocols in Immunology·S P James
Oct 1, 2020·International Journal of Molecular Sciences·Mohammed Tayab HussainLucy Victoria Norling
May 3, 1990·The New England Journal of Medicine·E D Harris
Aug 1, 1991·Clinical and Experimental Immunology·R A KayW E Ollier
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M KuwanaT M Wright
Jan 1, 1991·Clinical and Experimental Immunology·W WatsonC Harman
Jan 1, 1991·The International Journal of Biochemistry·V Kéry
Feb 1, 1991·Seminars in Arthritis and Rheumatism·I Joffe, S Epstein

❮ Previous
Next ❯

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