The control of hepatic iron uptake: correlation with transferring synthesis

British Journal of Haematology
A G Morton, A S Tavill

Abstract

The control of hepatic iron uptake was studied in the perfused liver isolated from rats subjected to nutritional iron deficiency. The total hepatic iron uptake and incorporation into ferritin was found to be higher in iron deficiency and during the 48 h of oral refeeding with iron than in the normal state. Specific incorporation of iron into feritin from a perfusate of normal transferrin iron saturation was enhanced in nutritional iron deficiency as compared to controls after 5 h of perfusion but not after 1 h, suggesting that increased uptake of iron from the perfusate may play a role in stimulating hepatic ferritin synthesis and assembly. This promotion of uptake into ferritin was inhibited by cycloheximide suggesting that enhanced incorporation of iron is dependent upon de novo synthesis of apoferritin. In control, nutritionally iron deficient and iron-refed rats there was a significant, direct correlation between the transferrin-iron saturation of the perfusate at physiological transferrin concentrations and total hepatic iron uptake after 5 h perfusion. A significant positive correlation was found between the hepatic total and ferritin iron uptake and the transferrin synthetic rate measured in the same liver. It is propose...Continue Reading

References

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Citations

Apr 1, 1993·Alcoholism, Clinical and Experimental Research·H ZhangB J Potter
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B Bomford, H N Munro
Oct 19, 2007·Critical Reviews in Clinical Laboratory Sciences·Anita C G ChuaJohn K Olynyk
Aug 1, 1980·British Journal of Haematology·E BakerA S Tavill
Mar 26, 2013·The Journal of Clinical Investigation·Shuling GuoStefano Rivella
Sep 12, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Qiong WuKazuhiro J Mori
Jun 19, 1984·Biochimica Et Biophysica Acta·K Thorstensen, I Romslo
Aug 17, 1984·Biochimica Et Biophysica Acta·K Thorstensen, I Romslo
Feb 16, 1983·Biochimica Et Biophysica Acta·E S Cole, J Glass

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