The control of liver regeneration by parathyroid hormone and calcium

Journal of Cellular Physiology
R H Rixon, J F Whitfield

Abstract

Following partial hepatectomy in rats, there were two bursts of hepatocyte DNA-synthetic and mitotic activity which were produced by two subpopulations having different rates of (nearly synchronous) proliferative development. Only about 50% of the cells in both subpopulations could initiate DNA synthesis and enter mitosis when exposed to the hypocalcemic conditions in the parathyroprivic rat for 24 hours before partial hepatectomy. The proliferatively incompetent hepatocytes in these hypocalcemic rats could be induced to initiate their DNA synthetic and mitotic activity by an intraperitoneal injection of the calcium-mobilizing parathyroid hormone (50 USP units/100 g) as late as 12 hours after partial hepatectomy. Single intraperitoneal injections of calcium (0.25 mg/100 g) could also restore the proliferative competence of these hepatocytes, but only when injected at specific periods following partial hepatectomy. The injection of calcium 12 to 15 hours after partial hepatectomy induced hepatocytes in the first subpopulation to finish their development and enter mitosis, but did not affect the second, more slowly developing, subpopulation. Calcium had to be injected 25 hours after partial hepatectomy to stimulate proliferation ...Continue Reading

References

Feb 1, 1972·CRC Critical Reviews in Biochemistry·H RasmussenA Tenenhouse
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S D BalkA C Braun
Jun 25, 1974·Prostaglandins·J P MacManus, J F Whitfield
Jan 1, 1974·The Journal of Membrane Biology·A B Borle
Jul 1, 1974·In Vitro·A L BoyntonH J Morton
Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R H Rixon, J F Whitfield
Jun 1, 1972·Journal of Cellular Physiology·R H Rixon, J F Whitfield
Oct 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·R H Rixon, J F Whitfield
Jan 1, 1971·Canadian Journal of Physiology and Pharmacology·A D Perris, J F Whitfield
May 1, 1957·British Medical Bulletin·R D HARKNESS

❮ Previous
Next ❯

Citations

Jan 1, 1987·Cancer Metastasis Reviews·J F WhitfieldP R Walker
Nov 1, 1979·Molecular and Cellular Biochemistry·J F WhitfieldB K Tsang
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·T Yoshikawa, H Terayama
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A L Boynton, J F Whitfield
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S H SwierengaS Karasaki
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R B Silver
Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·D KahnD H Van Thiel
Jan 1, 1980·Annals of the New York Academy of Sciences·J F WhitfieldS H Swierenga
Jan 1, 1980·Annals of the New York Academy of Sciences·H L Leffert, K S Koch
Jan 1, 1982·Bioscience Reports·A C Durham, J M Walton
Aug 14, 1986·Biochemical and Biophysical Research Communications·A R BuckleyD H Russell
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P Cornell
Apr 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FrancavillaV Mazzaferro
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J Díaz-GilP Escartín
May 1, 1989·Journal of Cellular Physiology·R H RixonJ F Whitfield
Mar 1, 1984·Journal of Cellular Physiology·R Campos GonzalesR H Rixon
Jan 1, 1978·Journal of Cellular Physiology·P R WalkerJ F Whitfield
Jan 1, 1981·Journal of Cellular Physiology·J P MacManus, J F Whitfield
Jan 1, 1979·Journal of Cellular Physiology·D Paul, H J Ristow
Jul 1, 1977·Journal of Cellular Physiology·R H RixonJ F Whitfield
Jul 1, 1988·Cell Biochemistry and Function·M J PujolO Bachs
Jan 1, 1980·Annals of the New York Academy of Sciences·S H SwierengaP R Walker
Mar 9, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julieta Díaz-Juárez, Rolando Hernández-Muñoz
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·A L Baker
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J St Hilaire, A L Jones
Jan 24, 1998·Archives of Biochemistry and Biophysics·M Díaz-MuñozR Hernández-Muñoz
Feb 1, 1995·Cellular Signalling·N TakuwaY Takuwa
Oct 16, 1978·Life Sciences·R Wondergem, V R Potter

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.