The control of locomotor frequency by excitation and inhibition.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Wen-Chang Li, Peter R Moult

Abstract

Every type of neural rhythm has its own operational range of frequency. Neuronal mechanisms underlying rhythms at different frequencies, however, are poorly understood. We use a simple aquatic vertebrate, the two-day-old Xenopus tadpole, to investigate how the brainstem and spinal circuits generate swimming rhythms of different speeds. We first determined that the basic motor output pattern was not altered with varying swimming frequencies. The firing reliability of different types of rhythmic neuron involved in swimming was then analyzed. The results showed that there was a drop in the firing reliability in some inhibitory interneurons when fictive swimming slowed. We have recently established that premotor excitatory interneurons [descending interneurons (dINs)] are critical in rhythmically driving activity in the swimming circuit. Voltage-clamp recordings from dINs showed higher frequency swimming correlated with stronger background excitation and phasic inhibition, but did not correlate with phasic excitation. Two parallel mechanisms have been proposed for tadpole swimming maintenance: postinhibition rebound firing and NMDAR-dependent pacemaker firing in dINs. Rebound tests in dINs in this study showed that greater backgrou...Continue Reading

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Citations

Dec 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jessica AusbornAbdeljabbar El Manira
Apr 25, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wen-Chang LiRoman Borisyuk
Mar 24, 2017·Journal of Neurophysiology·Erik SvenssonWen-Chang Li
Nov 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jared M CreggJerry Silver
Jul 20, 2018·Journal of Mathematical Neuroscience·Andrea FerrarioRoman Borisyuk
Aug 24, 2018·Nature Communications·Jianren SongAbdeljabbar El Manira
Jul 30, 2019·ELife·Rebecca A CallahanMartha W Bagnall
May 10, 2018·Frontiers in Cellular Neuroscience·Przemysław KurowskiPaweł Szulczyk
Oct 17, 2019·The Journal of Experimental Biology·Ari Berkowitz
Mar 16, 2019·Frontiers in Cellular Neuroscience·Wen-Chang Li, Stephen R Soffe
Oct 3, 2018·Frontiers in Neural Circuits·Eva M BergAbdeljabbar El Manira
Aug 28, 2020·Cell Chemical Biology·Alexandre M J GomilaPau Gorostiza

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