The control of neuromuscular transmission in health and disease

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Mark M Rich

Abstract

Multiple techniques are available to study failure of neuromuscular transmission. Electrophysiological techniques used in patients are well suited to detect failure of neuromuscular transmission; however, these methods offer little insight into the mechanisms underlying failure of transmission. More detailed techniques that are better suited for studying the underlying mechanisms can be performed in animal models of neuromuscular disease. However, it is often difficult to compare studies using different techniques to measure neuromuscular transmission. In this review, I discuss different techniques that are available to study failure of neuromuscular transmission. The strengths and weaknesses of various techniques are compared using several diseases as examples. The review concludes with a discussion of mechanisms that may contribute to failure of neuromuscular transmission during repetitive stimulation.

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Citations

Mar 19, 2013·The Veterinary Clinics of North America. Equine Practice·Manuel Martin-Flores
Mar 11, 2009·Journal of Critical Care·Torin D Shear, J A Jeevendra Martyn
Feb 19, 2009·Anaesthesia·J A J MartynL I Eriksson
Nov 19, 2011·Biochimica Et Biophysica Acta·Brian C GeyerHermona Soreq
Aug 24, 2017·Annals of Neurology·Ahmed A HawashMark M Rich
Nov 15, 2019·Annals of Neurology·Sabrina MetzgerMark M Rich
Oct 6, 2017·Annals of the New York Academy of Sciences·Xueyong Wang, Mark M Rich
Dec 19, 2016·Frontiers in Cellular Neuroscience·Dante J HerediaThomas W Gould
Oct 1, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·M John LuuDavid F Collins

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