The control of thyroid-specific gene expression: what exactly have we learned as yet?

Molecular and Cellular Endocrinology
Daniel Christophe

Abstract

The identification of transcription factors TTF 1 and Pax 8 and the demonstration of their pivotal role in thyroid development and in the control of thyroid-specific gene expression, although representing remarkable openings in our understanding of cell-specific transcription in the thyroid, still leave a lot of open questions. Recent work investigating the development of thyroid-specific gene expression in transgenic mouse models, now reveal that some basic assumptions have to be reconsidered also. Altogether, currently available data indicate that the regulatory machinery undergoes significant changes during thyroid organogenesis and confirm the existence of still unknown factors whose roles appear at least as critical as the ones played by TTF 1 and Pax 8 in the control of specific gene expression.

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Citations

Mar 7, 2006·The American Journal of Cardiology·Frederick L RubergGary J Balady
Aug 30, 2007·Thyroid : Official Journal of the American Thyroid Association·Ana Margarida MeirelesManuel Sobrinho-Simões
May 4, 2006·Pathology International·Ping ZhangKennichi Kakudo
Jul 23, 2011·The Journal of Clinical Endocrinology and Metabolism·Terry F DaviesRisheng Ma
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Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Juergen Kratzsch, Ferdinand Pulzer
Dec 15, 2012·Toxicology·Daniela GentilcoreConcetta Ambrosino
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Jul 15, 2018·Environmental Science and Pollution Research International·Clemilson Berto-JúniorLeandro Miranda-Alves
Feb 18, 2021·Echocardiography·Lin-Li ShengDan Han

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