The control of ventilation is dissociated from locomotion during walking in sheep

The Journal of Physiology
Philippe HaouziBernard Chalon

Abstract

This study was designed to test the hypothesis that the frequency response of the systems controlling the motor activity of breathing and walking in quadrupeds is compatible with the idea that supra-spinal locomotor centres could proportionally drive locomotion and ventilation. The locomotor and the breath-by-breath ventilatory and gas exchange (CO2 output (VCO2) and O2 uptake (VO2)) responses were studied in five sheep spontaneously walking on a treadmill. The speed of the treadmill was changed in a sinusoidal pattern of various periods (from 10 to 1 minute) and in a step-like manner. The frequency and amplitude of the limb movements, oscillating at the same period as the treadmill speed changes, had a constant gain with no phase lag (determined by Fourier analysis) regardless the periods of oscillations. In marked contrast, when the periods of speed oscillations decreased, the amplitude (peak-to-mean) of minute ventilation (VE) oscillations decreased sharply and significantly (from 6.1 +/- 0.4 l min(-1) to 1.9 +/- 0.2 l min(-1)) and the phase lag between ventilation and treadmill speed oscillations increased (to 105 +/- 25 degrees during the 1 min oscillation periods). VE response followed VCO2 very closely. The drop in VE am...Continue Reading

References

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Citations

Nov 6, 2007·Respiratory Physiology & Neurobiology·Philippe HaouziBernard Bihain
May 1, 2007·Respiratory Physiology & Neurobiology·Gregory D WellsJames Duffin
Mar 15, 2006·Respiratory Physiology & Neurobiology·Harold J Bell
Jan 18, 2006·Respiratory Physiology & Neurobiology·Philippe Haouzi
Oct 15, 2005·The Journal of Physiology·Philippe Haouzi, Bruno Chenuel
Feb 10, 2006·Journal of Applied Physiology·Tony G Waldrop, Gary A Iwamoto
Sep 4, 2013·The Journal of Physiology·Jerome A DempseyMarkus Amann
Sep 11, 2018·Frontiers in Physiology·Naoyuki EbineYoshiyuki Fukuoka

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