The controversial origin of pericytes during angiogenesis - Implications for cell-based therapeutic angiogenesis and cell-based therapies

Clinical Hemorheology and Microcirculation
Anna BlockiMichael Raghunath

Abstract

Pericytes reside within the basement membrane of small vessels and are often in direct cellular contact with endothelial cells, fulfilling important functions during blood vessel formation and homeostasis. Recently, these pericytes have been also identified as mesenchymal stem cells. Mesenchymal stem cells, and especially their specialized subpopulation of pericytes, represent promising candidates for therapeutic angiogenesis applications, and have already been widely applied in pre-clinical and clinical trials. However, cell-based therapies of ischemic diseases (especially of myocardial infarction) have not resulted in significant long-term improvement. Interestingly, pericytes from a hematopoietic origin were observed in embryonic skin and a pericyte sub-population expressing leukocyte and monocyte markers was described during adult angiogenesis in vivo. Since mesenchymal stem cells do not express hematopoietic markers, the latter cell type might represent an alternative pericyte population relevant to angiogenesis. Therefore, we sourced blood-derived angiogenic cells (BDACs) from monocytes that closely resembled hematopoietic pericytes, which had only been observed in vivo thus far. BDACs displayed many pericytic features an...Continue Reading

References

Jan 1, 1986·Tissue & Cell·D E Sims
Sep 1, 1987·The Journal of Cell Biology·A Orlidge, P A D'Amore
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·J ChesneyR Bucala
Jan 5, 2000·The Journal of Clinical Investigation·Y LinR P Hebbel
May 2, 2001·The Journal of Cell Biology·M HellströmC Betsholtz
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R AbeC N Metz
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I HartlappC N Metz
Dec 26, 2001·Microvascular Research·Ugur OzerdemWilliam B Stallcup
Jan 5, 2002·Circulation·Alexandra AbramssonChrister Betsholtz
Jan 22, 2003·Microvascular Research·Ana M Ponce, Richard J Price
Apr 26, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mihail HristovPeter C Weber
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
Dec 31, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Jin HurYoung-Bae Park
Oct 7, 2004·Circulation·C Farrington-RockA E Canfield
Aug 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Erzsebet KokovayLee A Cunningham
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Ugur OzerdemAndrew Li
Oct 11, 2005·Neuro-oncology·Gabriele Bergers, Steven Song
Oct 21, 2005·Cytotherapy·E M HorwitzUNKNOWN International Society for Cellular Therapy
Apr 12, 2006·The Journal of Experimental Medicine·Yoshihiro Yamada, Nobuyuki Takakura
May 11, 2006·Journal of Cell Science·Lindolfo da Silva MeirellesNance Beyer Nardi
Aug 5, 2006·Journal of Leukocyte Biology·Chrystelle Lamagna, Gabriele Bergers
Nov 23, 2006·Cancer Research·Elaine Y LinJeffrey W Pollard
Feb 13, 2007·Nature Cell Biology·Arianna DellavalleGiulio Cossu
Mar 12, 2008·Journal of Leukocyte Biology·Diane D ShaoDarrell Pilling
May 10, 2008·Seminars in Cancer Biology·Antonio SicaAlberto Mantovani
Jul 18, 2008·Nature Reviews. Cancer·Craig MurdochClaire E Lewis
Sep 13, 2008·Cell Stem Cell·Arnold I Caplan
Sep 13, 2008·Cell Stem Cell·Mihaela CrisanBruno Péault
Sep 20, 2008·Science·Wei TangJonathan M Graff
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Jan 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Konstantin GaengelChrister Betsholtz
May 11, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Mirko CorselliBruno Péault

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Citations

Sep 11, 2019·International Journal of Molecular Sciences·Anne Krüger-GengeFriedrich Jung
Jul 2, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jamie N MayoShawn E Bearden
Nov 28, 2019·Clinical Hemorheology and Microcirculation·H SieversR M Hirschberg
Apr 1, 2020·Clinical Hemorheology and Microcirculation·Mengru PangBiao Cheng
Apr 23, 2020·Frontiers in Aging Neuroscience·Maiko T UemuraJohn Q Trojanowski
Apr 23, 2019·Clinical Hemorheology and Microcirculation·Antje KremerHeike Walles
Oct 24, 2018·Clinical Hemorheology and Microcirculation·Sonia SalhaSanga Gehmert
Apr 16, 2019·Journal of Biological Engineering·Huaning Zhao, John C Chappell
Jan 5, 2021·Frontiers in Immunology·Juliane GustCameron J Turtle
Mar 30, 2021·Frontiers in Bioengineering and Biotechnology·Moldir ShyngysSebastian Beyer
Jun 21, 2021·Journal of Cancer Research and Clinical Oncology·Ruiqi ZhengAihua Gong

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