The controversial role of vitamin D in the skin: immunosuppression vs. photoprotection

Clinical and Experimental Dermatology
L A KuritzkyP H Hart

Abstract

Vitamin D is produced in the skin by ultraviolet (UV) B radiation (290-320 nm). The active metabolite 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is made systemically by hydroxylation of vitamin D in the liver and the kidney, but also locally in the epidermis, which suggests that 1,25(OH)(2)D(3) may have important functions in the skin. 1,25(OH)(2)D(3) has opposing effects: it can mimic immunosuppressive effects caused by UV irradiation in some models, or reverse UV-induced DNA damage and immunosuppression in other models. 1,25(OH)(2)D(3) exerts effects on Langerhans cells that are characteristic of those associated with UV radiation (UVR)-induced suppression of contact hypersensitivity, and topical application of the vitamin D analogue calcipotriene suppresses contact hypersensitivity in human subjects to a similar extent as UVR. However, 1,25(OH)(2)D(3) decreases DNA damage both in vitro when added to human skin cells in culture before and after UVR, and in vivo when applied to mouse skin after UVR. Furthermore, topical 1,25(OH)(2)D(3) applied to mouse skin after UVR reversed the immunosuppressive effect of UVR in a contact hypersensitivity model. This review will discuss the role of 1,25(OH)(2)D(3) as either a mediator of U...Continue Reading

References

Apr 3, 2002·Trends in Molecular Medicine·Chantal Mathieu, Luciano Adorini
Apr 12, 2003·Journal of Cellular Biochemistry·Jörg Reichrath, Gunter Rappl
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·G WongR S Mason
Jul 26, 2005·The Journal of Steroid Biochemistry and Molecular Biology·K M DixonR S Mason
Sep 16, 2005·Photochemistry and Photobiology·Bodo Lehmann
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiangyang DongMatthew D Griffin
Mar 28, 2006·Progress in Biophysics and Molecular Biology·Mary Norval
Oct 18, 2006·Archives of Dermatology·Kaija K HannemanElma D Baron
Dec 16, 2006·The Journal of Investigative Dermatology·Ritu GuptaRebecca S Mason
Jan 16, 2007·The Journal of Steroid Biochemistry and Molecular Biology·K M DixonR S Mason
Mar 8, 2007·Critical Reviews in Eukaryotic Gene Expression·R Khanal, Ilka Nemere

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Citations

Jan 1, 2009·American Journal of Clinical Dermatology·Evelyn R Gonzaga
Sep 2, 2015·Expert Review of Vaccines·Sapna P SadaranganiGregory A Poland
May 21, 2009·Developmental and Comparative Immunology·Blake C EllisMark S Kindy
Nov 29, 2013·Photodermatology, Photoimmunology & Photomedicine·Suzanne M PilkingtonLesley E Rhodes
Aug 29, 2012·Dermato-endocrinology·Asta Juzeniene, Johan Moan
Dec 22, 2012·The Lancet Infectious Diseases·Anna P RalphMary Norval
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Katie M DixonRebecca S Mason
Jul 24, 2018·Case Reports in Pediatrics·Christina BothouDimitrios T Papadimitriou
Aug 18, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Shelley Gorman, Prue H Hart
Aug 28, 2021·International Journal of Molecular Sciences·Georgeta BochevaAndrzej T Slominski
Mar 2, 2010·Journal of the American Academy of Dermatology·Jamie ZussmanJenny Kim

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