PMID: 9531419Apr 8, 1998Paper

The contryphans, a D-tryptophan-containing family of Conus peptides: interconversion between conformers

The Journal of Peptide Research : Official Journal of the American Peptide Society
R JacobsenB M Olivera

Abstract

We previously characterized contryphan-R, a D-tryptophan-containing octapeptide from the venom of Conus radiatus. In this study, we present evidence that the contryphan family of peptides is widely distributed in venoms of the fish-hunting cone snails. We purified, synthesized and characterized contryphan-Sm from Conus stercusmuscarum venom, and obtained molecular evidence for the existence of a third peptide, contryphan-P from Conus purpurascens venom ducts. The sequences of these three contryphans showed identity in seven of eight amino acids and a conserved pattern of post-translational modification. We also demonstrate that contryphan-Sm equilibrates between two distinct conformational states.

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Citations

Feb 17, 2006·FEBS Letters·Allan M TorresPhilip W Kuchel
Aug 1, 2009·Natural Product Reports·Reena Halai, David J Craik
Jun 24, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Konkallu H GowdBaldomero M Olivera
Jun 7, 2015·Analytical and Bioanalytical Chemistry·Alena M RodriguezFrank Marí
Aug 26, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·R B JacobsenB M Olivera
Jan 30, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·A SchulzK Adermann
Feb 8, 2014·PloS One·Samuel D RobinsonAnthony T Papenfuss
Dec 17, 2010·Cellular and Molecular Life Sciences : CMLS·Felipe CavaMatthew K Waldor
May 22, 2010·Bioanalytical Reviews·Lu BaiJonathan V Sweedler
Oct 26, 2002·The Journal of Biological Chemistry·Michael FerberHeinrich Terlau
Jun 5, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Céline OllivauxJean-Yves Toullec
May 25, 2015·Asian Pacific Journal of Tropical Medicine·Palanisamy Satheesh KumarSundaresan Umamaheswari
Jan 7, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Axel SchulzKnut Adermann
Dec 19, 2014·Marine Drugs·Samuel D Robinson, Raymond S Norton
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Oct 2, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·David H MastJonathan V Sweedler
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