Abstract
Although patients with cryptogenic cirrhosis have historically been considered as having "burnt-out" non-alcoholic steatohepatitis (NASH), some controversy remains. The aim of this study was to compare outcomes of patients with cryptogenic cirrhosis and NASH-related cirrhosis from a cohort with longitudinal follow-up data. Patients with cryptogenic cirrhosis or NASH cirrhosis were screened for a clinical trial. Patients with <5% hepatic steatosis regardless of other histologic features were considered to have cryptogenic cirrhosis. Clinico-laboratory data and adjudicated liver-related events (e.g. decompensation, qualification for transplantation, death) were available. A total of 247 patients with cirrhosis (55.3 ± 7.4 years, 37% male) were included; 144 had NASH cirrhosis and 103 had cryptogenic cirrhosis. During a median follow-up of 29 (IQR 21-33) months (max 45 months), 20.6% of patients had liver-related clinical events. Patients with NASH cirrhosis and cryptogenic cirrhosis were of a similar age and gender, as well as having a similar body mass index, PNPLA3 rs738409 genotype, and prevalence of diabetes (p >0.05). However, patients with cryptogenic cirrhosis had higher serum fibrosis markers and greater collagen content ...Continue Reading
Citations
Apr 9, 2019·Alimentary Pharmacology & Therapeutics·Emma NilssonHanne Prytz
Jun 15, 2020·Digestive Diseases and Sciences·Christopher J DanfordMichelle Lai
Sep 15, 2020·Hepatology Communications·Sang Bong AhnPatricia C Valery
Feb 19, 2020·International Journal for Equity in Health·Patricia C ValeryElizabeth E Powell
Nov 9, 2019·Hepatology International·Pegah GolabiZobair M Younossi
Aug 10, 2019·Seminars in Diagnostic Pathology·Ilke Nalbantoglu, Dhanpat Jain
Oct 27, 2020·Endocrinology, Diabetes & Metabolism·Stephanie O Omokaro, Julie K Golden
Mar 18, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Catherine F SilvaClaudia A Couto
Apr 4, 2021·Journal of Clinical Medicine·Raluca Pais, Thomas Maurel
May 1, 2020·Gastroenterology·Mazen NoureddinUNKNOWN Liver Forum NASH Cirrhosis Working Group
Apr 25, 2021·Lancet·Elizabeth E PowellMary Rinella
Apr 26, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Javier AmpueroUNKNOWN HEPAmet Registry
Feb 26, 2020·Internal Medicine Journal·Patricia C ValeryElizabeth E Powell
Jun 3, 2021·Cancers·Gian Paolo CavigliaElisabetta Bugianesi
Jun 14, 2021·The American Journal of Pathology·Lingtong MengYuji Nishikawa
Jul 10, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Jesús Rivera-EstebanElisabetta Bugianesi
Aug 8, 2021·Cells·Christian von LoeffelholzAndreas L Birkenfeld
Apr 12, 2020·Journal of Hepatology·Mohammed EslamJacob George
Dec 23, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Luca ValentiUtpal Pajvani
Jan 22, 2022·Expert Opinion on Investigational Drugs·Pankaj AggarwalNaim Alkhouri