The conundrum of the Epstein-Barr virus-associated gastric carcinoma in the Americas

Oncotarget
Gonzalo Carrasco-AvinoAlejandro Corvalán

Abstract

Epstein-Barr virus-associated gastric carcinoma shows a higher prevalence in the Americas than Asia. We summarize all studies of Epstein Barr virus-associated gastric carcinoma in the Americas, focusing on host characteristics, environmental associations and phylogeographic diversity of Epstein-Barr virus strains. In the Americas, the prevalence of Epstein Barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. EBERs, EBNAs, BARTs and LMP are the highest expressed genes; their variations in healthy individuals may explain the phylogeographic diversity of Epstein-Barr virus across the region. Gastric cancer cases harbor exclusively the western genotype (subtype D and kept Xho I site), suggesting a disrupted co-evolution between the pathogen and its host. Epstein-Barr virus-associated gastric carcinoma molecular subtype cases from The Cancer Genome Atlas display PIK3CA gene mutations, amplification of JAK2, PD-L1 and PD-L2 and CpG island methylator phenotype, leading to more extensive methylation of host and viral genomes than any other subtypes from the study. Environmental conditions include negative- and positive- associations with being firstborn child and smo...Continue Reading

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Citations

Apr 21, 2018·Frontiers in Microbiology·Iva PolakovicovaAlejandro H Corvalán
Jan 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Keila TorresAlejandro H Corvalan
Apr 23, 2020·Archives of Pathology & Laboratory Medicine·Zainab I Alruwaii, Elizabeth A Montgomery
Jul 2, 2021·Infectious Agents and Cancer·Francisco AguayoRancés Blanco
Oct 28, 2021·Journal of Cancer Research and Clinical Oncology·Yide WongJohn J Miles

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RNAseq

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GLOBOCAN

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