The convergence-divergence duality in lectin domains of selectin family and its implications

FEBS Letters
K C Chou

Abstract

A comparison of the three-dimensional structures of P-, L-, and E-selectin lectin domains reveals that there is a convergence-divergence duality for the 77-107 polypeptide in the three domains; i.e. part of the peptide is folded into a closely similar conformation, and part of it into a highly different one. Since the 77-107 residues are associated with the putative binding sites of the selectin family for ligands, this kind of duality might well reflect the common character of ligands to the selectin family as well as the specificity to each of their respective receptors. The finding may be of use for rationally designing selectin inhibitors with a given specificity and possible antiadhesion drugs.

References

Jan 20, 1992·Journal of Molecular Biology·K C Chou
Jan 1, 1991·Proteins·K C Chou, L Carlacci
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M H Siegelman, I L Weissman
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M P BevilacquaM A Gimbrone
Jan 5, 1989·Journal of Molecular Biology·K C ChouH A Scheraga
Mar 14, 1986·Cell·M GallatinI L Weissman
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua

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Citations

May 2, 2012·Journal of Biomolecular Structure & Dynamics·Shen NiuKuo-Chen Chou
Jun 22, 2012·PloS One·Bi-Qing LiKuo-Chen Chou
Mar 22, 2014·International Journal of Molecular Sciences·Yue-Nong FanKuo-Chen Chou
Nov 12, 2013·Journal of Theoretical Biology·Sweta KumariMohammad Tauqueer
May 25, 2004·Journal of Chemical Information and Computer Sciences·Suzanne SiroisKuo-Chen Chou
Dec 29, 2013·BioMed Research International·Jian-Liang MinKuo-Chen Chou
May 2, 2006·Biochemical and Biophysical Research Communications·Dong-Qing WeiKuo-Chen Chou
Apr 4, 2000·FEBS Letters·K C ChouR L Heinrikson
Oct 20, 2000·Analytical Biochemistry·K C Chou
Dec 21, 2010·Journal of Theoretical Biology·Kuo-Chen Chou

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