The convergent epidemiology of tuberculosis and human cytomegalovirus infection

F1000Research
Frank CobelensHelen Fletcher

Abstract

Although several factors are known to increase the risk of tuberculosis, the occurrence of tuberculosis disease in an infected individual is difficult to predict. We hypothesize that active human cytomegalovirus infection due to recent infection, reinfection or reactivation plays an epidemiologically relevant role in the aetiology of tuberculosis by precipitating the progression from latent tuberculosis infection to disease. The most compelling support for this hypothesis comes from the striking similarity in age-sex distribution between the two infections, important because the age-sex pattern of tuberculosis disease progression has not been convincingly explained. Cytomegalovirus infection and tuberculosis have other overlapping risk factors, including poor socio-economic status, solid organ transplantation and, possibly, sexual contact and whole blood transfusion. Although each of these overlaps could be explained by shared underlying risk factors, none of the epidemiological observations refute the hypothesis. If this interaction would play an epidemiologically important role, important opportunities would arise for novel approaches to controlling tuberculosis.

References

Nov 1, 1978·Annals of Internal Medicine·N A Tolkoff-RubinM S Hirsch
May 1, 1976·American Journal of Epidemiology·A R HinmanP B Daitch
Jan 1, 1990·American Journal of Epidemiology·Z LiuD Sackett
Jul 1, 1990·The Journal of Infectious Diseases·A C CollierL Corey
Jan 1, 1990·Comparative Immunology, Microbiology and Infectious Diseases·O D OlaleyeS S Baba
Apr 1, 1989·Clinical Microbiology Reviews·B A Forbes
Apr 1, 1987·The Journal of Infectious Diseases·S H ChandlerJ K McDougall
Jul 1, 1986·American Journal of Epidemiology·G W Comstock
Apr 1, 1985·Chest·D E Snider
Feb 1, 1974·American Journal of Epidemiology·G W ComstockS F Woolpert
May 8, 1980·The New England Journal of Medicine·S StagnoC A Alford
Nov 1, 1983·Reviews of Infectious Diseases·S P Adler
May 1, 1983·The Journal of Infectious Diseases·W W Stead, J P Lofgren
Jan 1, 1995·American Journal of Epidemiology·W H Frost
Sep 1, 1993·Journal of Virology·M BalthesenM J Reddehase
Mar 1, 1996·The Journal of Pediatrics·J F BaleJ R Murph
Feb 20, 1998·The Pediatric Infectious Disease Journal·M VochemC P Speer
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·M F CantwellI M Onorato
Jun 3, 1999·Transfusion Medicine·D H PamphilonL M Williamson
Jul 19, 2000·Current Opinion in Immunology·M J Reddehase
May 3, 2001·The New England Journal of Medicine·S B BoppanaW J Britt
May 19, 2001·Revista de saúde pública·L N AlmeidaE Massad
Jun 16, 2001·Nephron·K J ChouH M Chung
Oct 17, 2001·The Journal of General Virology·S PignatelliM P Landini
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·R BroschS T Cole
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina A FreudenbergChris Galanos
Dec 1, 1954·American Review of Tuberculosis·L D ZEIDBERG, A DILLON
Mar 17, 1956·British Medical Journal·P A THORNJ A WATERHOUSE
Aug 5, 2005·International Journal of Cancer. Journal International Du Cancer·Fang-Hui ZhaoYou-lin Qiao
Oct 5, 2005·PLoS Pathogens·M Cristina GutierrezVeronique Vincent
Dec 2, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Claudia MancaGilla Kaplan
Jun 27, 2006·Transplantation Proceedings·I ErgunB Erbay
Sep 8, 2006·Clinical and Vaccine Immunology : CVI·Holly SealeLyn Gilbert
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephanie A S StarasMichael J Cannon
Mar 6, 2007·Experimental Gerontology·Raymond P StoweRonald Glaser
Mar 23, 2007·Journal of Virology·David J C MilesArnaud Marchant
Dec 1, 1939·American Journal of Public Health and the Nation's Health·A S PopeD Zacks

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Citations

Oct 27, 2018·Seminars in Immunopathology·David Hertz, Bianca Schneider
Jul 12, 2019·Frontiers in Pediatrics·Elizabeth WhittakerJames A Seddon
Nov 8, 2019·JCI Insight·Julius MüllerHelen A Fletcher
Nov 12, 2019·Respiratory Medicine Case Reports·Kai Chin Poh, Shuwei Zheng

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