May 1, 1996

The copper complex of captopril is not a superoxide dismutase mimic. Artefacts in DMPO spin trapping

Free Radical Research
M BartoszG Bartosz

Abstract

The effect of captopril and of its copper complex on several superoxide-dependent reactions used to detect and assay superoxide dismutase activity was studied, including pyrogallol and hematoxylin autoxidation and Nitro Blue Tetrazolium reduction. In none of these systems were superoxide dismutase-like properties of captopril/Cu apparent. Captopril/Cu decreased the yield of DMPO-OH adducts generated by KO2 but this effect may be due to the acceleration of the decay of the adduct by captopril/Cu.

  • References8
  • Citations4

Mentioned in this Paper

Cyclic N-Oxides
Spin Labels
Lopirin
Antioxidant Effect
Morphologic Artifacts
Copper
Free Radical Scavengers
5,5-dimethyl-1-pyrroline-1-oxide
Spin Trapping
Ag-Zn Superoxide Dismutase

About this Paper

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