The corepressor Atrophin specifies odorant receptor expression in Drosophila

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Liza AlkhoriMattias Alenius

Abstract

In both insects and vertebrates, each olfactory sensory neuron (OSN) expresses one odorant receptor (OR) from a large genomic repertoire. How a receptor is specified is a tantalizing question addressing fundamental aspects of cell differentiation. Here, we demonstrate that the corepressor Atrophin (Atro) segregates OR gene expression between OSN classes in Drosophila. We show that the knockdown of Atro result in either loss or gain of a broad set of ORs. Each OR phenotypic group correlated with one of two opposing Notch fates, Notch responding, Nba (N(on)), and nonresponding, Nab (N(off)) OSNs. Our data show that Atro segregates ORs expressed in the Nba OSN classes and helps establish the Nab fate during OSN development. Consistent with a role in recruiting histone deacetylates, immunohistochemistry revealed that Atro regulates global histone 3 acetylation (H3ac) in OSNs and requires Hdac3 to segregate OR gene expression. We further found that Nba OSN classes exhibit variable but higher H3ac levels than the Nab OSNs. Together, these data suggest that Atro determines the level of H3ac, which ensures correct OR gene expression within the Nba OSNs. We propose a mechanism by which a single corepressor can specify a large number of ...Continue Reading

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Citations

Jun 20, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Scott Barish, Pelin Cayirlioglu Volkan
Jan 15, 2016·PLoS Genetics·Qingyun LiPelin Cayirlioglu Volkan
Apr 15, 2018·Neural Development·Hongjie LiLiqun Luo
Jun 10, 2020·Neotropical Entomology·C Villagra, D Frías-Lasserre
Feb 9, 2019·Nature Communications·Phing Chian ChaiRichard Benton
Sep 15, 2018·Frontiers in Cellular Neuroscience·Carolina Gomez-DiazEsther Alcorta
Feb 9, 2020·The Journal of Experimental Biology·Hua YanClaude Desplan

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