The coronary calcium score is a more accurate predictor of significant coronary stenosis than conventional risk factors in symptomatic patients: Euro-CCAD study

International Journal of Cardiology
R NicollM Henein

Abstract

In this retrospective study we assessed the predictive value of the coronary calcium score for significant (>50%) stenosis relative to conventional risk factors. We investigated 5515 symptomatic patients from Denmark, France, Germany, Italy, Spain and the USA. All had risk factor assessment, computed tomographic coronary angiogram (CTCA) or conventional angiography and a CT scan for coronary artery calcium (CAC) scoring. 1539 (27.9%) patients had significant stenosis, 5.5% of whom had zero CAC. In 5074 patients, multiple binary regression showed the most important predictor of significant stenosis to be male gender (B=1.07) followed by diabetes mellitus (B=0.70) smoking, hypercholesterolaemia, hypertension, family history of CAD and age but not obesity. When the log transformed CAC score was included, it became the most powerful predictor (B=1.25), followed by male gender (B=0.48), diabetes, smoking, family history and age but hypercholesterolaemia and hypertension lost significance. The CAC score is a more accurate predictor of >50% stenosis than risk factors regardless of the means of assessment of stenosis. The sensitivity of risk factors, CAC score and the combination for prediction of >50% stenosis when measured by convent...Continue Reading

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Citations

Sep 15, 2016·European Heart Journal Cardiovascular Imaging·Filippo CademartiriErica Maffei
Jan 18, 2018·International Journal of Molecular Sciences·Usama BolesMichael Y Henein
Oct 7, 2017·Pacing and Clinical Electrophysiology : PACE·Nataliia BotsvaDmitriy Chernetchenko
Apr 29, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N AhmadiM Budoff
Nov 2, 2016·Journal of the American Heart Association·Ysoline BeigneuxDavid Calvet
Apr 7, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Yuri Akishima-FukasawaToshiharu Ishii
Nov 14, 2018·Journal of Computer Assisted Tomography·Nagina MalguriaElliot K Fishman
Jan 30, 2020·Diagnostics·Michael Y HeneinFederico Vancheri
Sep 25, 2019·Diagnostics·Federico VancheriMichael Y Henein
Oct 28, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D Rijlaarsdam-HermsenP R M van Dijkman
Mar 10, 2017·Current Treatment Options in Cardiovascular Medicine·Negin NezaratMatthew Budoff
Apr 16, 2019·Medicine·Urban HellmanMichael Henein
Apr 29, 2020·International Journal of Molecular Sciences·Nataliya V MushenkovaAlexander N Orekhov
Oct 3, 2018·European Heart Journal Cardiovascular Imaging·Michael J Zellweger

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