The correlation analysis of miRNAs and target genes in metastasis of cervical squamous cell carcinoma

Epigenomics
Jing ZhouChangzhong Li

Abstract

This study was intended to identify the metastasis-related miRNAs and target genes in cervical squamous cell carcinoma. The mRNA and miRNA next-generation sequencing data were downloaded. Differential expression analysis was carried out, followed by target gene prediction of differentially expressed miRNAs. The biological function of differentially expressed genes was performed. Validation was carried out by survival analysis and qRT-PCR. N4BP3 were associated with the survival time of patients. Hsa-mir-451 and hsa-mir-486 were related to tumor differentiation stage. Validated expression of hsa-mir-24-2, hsa-mir-582, NOTCH1, PIP4K2B, DIP2B and IGFBP5 was consistent with the bioinformatics analysis. Alterations of miRNAs and target genes may be useful in understanding the metastasis mechanisms of cervical squamous cell carcinoma.

References

Citations

Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P ZagourasS Artavanis-Tsakonas
Feb 1, 1993·Journal of Clinical Pathology·R J HaleF L Wilcox
Aug 4, 2004·Seminars in Cancer Biology·Katerina PolitiJan Kitajewski
Sep 23, 2006·Developmental Biology·Baohong ZhangTodd A Anderson
Feb 10, 2007·International Journal of Cancer. Journal International Du Cancer·Takashi MiyatakeTakayuki Enomoto
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eva BandresJesus Garcia-Foncillas
Dec 3, 2009·British Journal of Cancer·S SrivastavaS Krishna
Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhibin HuH Shen
Apr 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gloria S HuangSusan Band Horwitz
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Dec 15, 2010·Bioinformatics·Michael E SmootTrey Ideker
Jan 25, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kristen M FossGlen J Weiss
Mar 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hue-Kian OhPatrick Tan
May 27, 2011·Genome Research·Agustin F FernandezManel Esteller
Sep 6, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaogang TanJie He
May 11, 2012·Nucleic Acids Research·Daniel Tabas-MadridAlberto Pascual-Montano
Sep 18, 2012·The International Journal of Biochemistry & Cell Biology·Zuoren YuR G Pestell
Oct 3, 2012·PloS One·Santosh K PatnaikAnil Vachani
Nov 10, 2012·International Journal of Biological Sciences·Zofia WotschofskyKlaus Jung
Jan 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Keita UchinoTakahiro Ochiya
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stefano Volinia, Carlo M Croce
Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yong PengCarlo M Croce
Sep 21, 2013·Neural Development·Michael J SchmeisserTobias M Boeckers
Nov 19, 2013·Oncogene·X SunR G Pestell

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