PMID: 1187284Nov 1, 1975Paper

The correlation between exercise-induced bronchoconstriction and bronchial methacholine sensitivity in asthma.

Pediatrics
J Kiviloog

Abstract

A possible relationship between exercise-induced bronchoconstriction (EIB) and bronchial sensitivity to the cholinergic drug, metacholine, was studied. On the same day, 57 asthmatic subjects inhaled increasing concentrations of the drug and were then tested for EIB by exercising to exhaustion. A fall in peak expiratory flow rate of 15% or more was considered a positive reaction to either test. Of the 45 patients exhibiting a positive methacholine reaction, 33 showed bronchoconstriction after exercise (including three of the ten who had no previous history of exertional asthma) while none of the 12 methacholine nonreactors developed EIB. This significant correlation (P is less than .001) between the tendency to develop EIB and sensitivity to methacholine suggests that bronchoconstriction, induced either by exercise or methacholine, is a specific reaction.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.