PMID: 6159992Sep 1, 1980Paper

The correlation between increased reactivity of the bronchi and of mediator releasing cells in asthma

Clinical Allergy
H J NeijensK F Kerrebijn

Abstract

The hypothesis that increased reactivity in asthma is not always limited to the bronchi but also exists in the mediator releasing system was investigated in forty-five asthmatic children, approximately half of whom had exercise-induced bronchoconstriction (EIB). The bronchial threshold to histamine was measured as an indicator of the reactivity of the bronchi and the histamine release from leucocytes without adding allergen (spontaneous histamine release) was considered as an indicator of the reactivity of the basophil leucocytes. There was a significant correlation between the histamine threshold and spontaneous histamine release and between these and EIB. These findings support the hypothesis.

References

Sep 1, 1976·The Journal of Allergy and Clinical Immunology·C D May
Dec 1, 1979·The Journal of Allergy and Clinical Immunology·H J NeijensK F Kerrebijn
Feb 1, 1978·Clinical Immunology and Immunopathology·W K Podleski, J R Grimes
Feb 1, 1979·The Journal of Allergy and Clinical Immunology·P A Eggleston
Nov 1, 1977·The Journal of Allergy and Clinical Immunology·R A SimonE M Tan
Sep 7, 1968·British Medical Journal·S E Davies
Apr 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·J E MOORE, G W JAMES

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Citations

Oct 1, 1993·Allergy·J L CorhayM F Radermecker
Sep 1, 1990·The American Review of Respiratory Disease·R GradR J Lemen
Sep 1, 1988·The Journal of Allergy and Clinical Immunology·H J DegenhartH J Neijens
Sep 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·C J HillidgeT J Lane
Jul 1, 1983·Allergy·S D Anderson
Apr 1, 1989·The Journal of Allergy and Clinical Immunology·K Akagi, R G Townley

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