The correlation between magnetic resonance imaging features of the brainstem and cerebellum and clinical features of spinocerebellar ataxia 3/Machado-Joseph disease

Neurology India
Xiao-chun LiangBei-sha Tang

Abstract

Brainstem and cerebellar atrophy are the most important features in magnetic resonance imaging (MRI) in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). However, the correlation between brainstem and cerebellar atrophy and the clinical features has not been well studied. To study the correlation between MRI features of the brainstem and cerebellum and predominant clinical features in SCA3/MJD. University teaching hospital. By using the linear measurement method, we assessed 32 patients with SCA3/MJD to study the correlations between the morphometric data of the brainstem and cerebellum and clinical features: Duration of the disease, age of onset, total international cooperative ataxia rating scale (ICARS) score; total scale for the assessment and rating of ataxia (SARA) score; ICARS subscores, and SARA subscores. Pearson correlation test. There was a significant inverse correlation between anteroposterior diameter of the midbrain and pons and total ICARS scores, total SARA scores, ICARS and SARA subscores (r = -0.381 approximately -0.57, P < 0.05 or 0.01) and disease duration (r = -0.42 approximately -0.51, P < 0.05 or 0.01). Additionally, superoinferior diameter of the cerebellum was inversely correlated with t...Continue Reading

Citations

Apr 5, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Rachel P GuimarãesFernando Cendes
Aug 28, 2020·Frontiers in Neuroscience·Na WanHong Jiang

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