The correlation between mammographic densities and molecular pathology in breast cancer

Cancer Biomarkers : Section a of Disease Markers
Yu JiPeifang Liu

Abstract

This study aimed to analyze the correlation between mammographic density obtained by density analysis software (DAS)/radiologists visual (RV) classification with molecular subtype, and the expression levels of estrogen receptor (ER), progesterone receptor (PR), Ki67 antigen (Ki-67), p53 gene (p53), and human epidermal growth factor receptor-2 (HER2). A total of 688 breast cancer patients with digital mammography and complete molecular pathological results in Tianjin Medical University Cancer Institute and Hospital between February 2015 and February 2016 were collected. The DAS-density grade (DASD) and the radiologists visually classified density grade (RVD) were evaluated by 3 radiologists. The correlation between density grade and the expression levels of ER, PR, Ki-67, p53, HER2 and breast cancer molecular subtype (PMS) were analyzed. The agreement between DASD and RVD was explored. ER, PR and HER-2 positive rate were significantly different among patients with different RVD grades (P< 0.05). HER2 positive rates showed an increasing trend following RVD upgrading (P

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Citations

Jun 10, 2019·Breast Cancer Research and Treatment·Michael S ShawkyErik W Thompson
Jun 30, 2019·Breast Cancer Research and Treatment·Erni LiXiaohong R Yang
Feb 23, 2021·Journal of Healthcare Engineering·Jingjing YangYanan Liu
Jan 2, 2019·Pathology, Research and Practice·Sandra RadenkovicVladimir Jurisic

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