The correlation between placental pathology and intraventricular hemorrhage in the preterm infant. The Developmental Epidemiology Network Investigators

Pediatric Research
D DiSalvo

Abstract

The aim of this study is to better understand the relationship between placental pathology and risk of intraventricular hemorrhage (IVH). We address two specific hypotheses. 1) Morphologic correlates of pregnancy-induced hypertension (PIH) are associated with a decreased risk of IVH. 2) Morphologic correlates of amniotic sac inflammation (ASI) are associated with an increased risk of IVH. Maternal, neonatal, and placental data were analyzed by univariate and multivariate methods in this prospective cohort study of 1095 very low birth weight infants. A cluster analysis model was used to categorize the placental pathologic features into clusters, the two main ones being PIH and ASI. Deliveries were subdivided by the interval between membrane rupture and delivery as an index of preexisting infection (<1 h) and ascending infection (> or =1 h). Univariate analysis supports both hypotheses. However, in multivariate models that adjusted for such potential confounders as gestational age, labor, and route of delivery, the only associations that persisted were the increased risk of IVH associated with the presence of chorionic or umbilical vasculitis in infants born within 1 h of membrane rupture. Placental correlates of PIH do not provi...Continue Reading

References

Nov 1, 1992·The Journal of Pediatrics·L R MentR W Makuch
Jul 1, 1992·Paediatric and Perinatal Epidemiology·M O'SheaK A Feinstein
Aug 1, 1988·American Journal of Obstetrics and Gynecology·R BejarR Resnik
Apr 1, 1987·Developmental Medicine and Child Neurology·M L WilliamsD B D'Eugenio
Jul 1, 1994·Journal of Neuropathology and Experimental Neurology·M R Grafe
Jun 1, 1993·Developmental Medicine and Child Neurology·A Leviton
Jun 1, 1996·American Journal of Public Health·R L Goldenberg, W W Andrews
Mar 1, 1996·The Journal of Pediatrics·J K GretherS K Cummins

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Citations

Oct 10, 2009·Pediatric Research·Praveen Ballabh
May 1, 2009·Pediatrics·I Nicholas OlomuUNKNOWN Extremely Low Gestational Age Newborn Study Investigators
Jun 27, 2014·BioMed Research International·Sophie BrouilletPascale Hoffmann
Dec 3, 2016·Scientific Reports·Devasuda AnblaganJames P Boardman
Jul 9, 2010·Annals of Medicine·Hanna KallankariMikko Hallman
Feb 13, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·Jane E StewartMarcello Pagano
May 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet R AsogluKatherine R Goetzinger
May 30, 2009·Journal of Neuroscience Research·Heather Morein FrenchJudith B Grinspan
Jan 11, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Milla YlijokiUNKNOWN PIPARI study group
Feb 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Olaf DammannChristiane E L Dammann
Feb 20, 2010·Obstetrics and Gynecology·Zahra MalekiErnest M Graham
Feb 15, 2014·Clinics in Perinatology·Vann ChauSteven P Miller
Sep 12, 2013·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Guangju Luo, Raymond W Redline
Jul 15, 2004·Seminars in Neonatology : SN·Raymond W Redline
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Jun 4, 1999·The Journal of Pediatrics·A LevitonM Pagano
Apr 16, 2008·The Journal of Pediatrics·Milla ReimanUNKNOWN PIPARI Study Group

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