The correlation between serum prostate-specific antigen and prostate cancer is not influenced by the serum testosterone concentration

Urology
J M MondaJ E Oesterling

Abstract

To determine if the serum testosterone (T) concentration influences the ability of prostate-specific antigen (PSA) to predict prostate cancer volume and stage. One hundred consecutive patients with clinically localized prostate cancer who underwent radical prostatectomy were examined prospectively. Each patient was evaluated preoperatively with a serum PSA, total T, free T, and percent free T. All surgical specimens were evaluated using the whole mount, step section technique for Gleason score, tumor volume, and extraprostatic disease. Serum total T, free T, and percent free T did not correlate with the serum PSA level (r = .03, .08, and .07, respectively), tumor volume (r = .11, .08, and .11, respectively), prostate weight (r = .00, -.08, and .11, respectively), or Gleason score (r = .11, .08, and .11, respectively). Serum PSA correlated with tumor volume (r = .51, P < 0.0001). Extraprostatic disease was significantly associated with a higher percent free T value (r = .26, P = 0.02) but not with either the total or the free T level. Linear regression analysis showed that neither the total nor the free T concentration was a significant predictor of extraprostatic disease in the presence of PSA (P = 0.30 and 0.24, respectively);...Continue Reading

References

Jan 1, 1990·Chronobiology International·J M Dabbs
Oct 8, 1987·The New England Journal of Medicine·T A StameyE Redwine
Jun 1, 1993·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·S M SchraderS D Simon
Sep 1, 1896·Annals of Surgery·A T Cabot

❮ Previous
Next ❯

Citations

Aug 1, 1997·International Journal of Radiation Oncology, Biology, Physics·G K Zagars, A Pollack
Feb 22, 2002·BJU International·K SairamT A McNicholas
Aug 12, 1998·British Journal of Urology·P FitzpatrickJ M Fitzpatrick
Jun 3, 2009·Brain, Behavior, and Immunity·Emma L TurnerKavita Vedhara
Apr 10, 2007·Cancer Detection and Prevention·Yoshitaka SekineKazuhiro Suzuki
Feb 25, 2000·The Journal of Urology·M A HoffmanA Morgentaler
Oct 1, 1996·The Journal of Urology·E L Wynder, W R Fair
May 21, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Pedro Henrique Oliveira CabralSidney Glina
Sep 10, 2019·Expert Opinion on Drug Safety·Abraham Morgentaler, Monica Caliber
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen J FreedlandChristopher J Kane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.