The correlation between the regulation of recombinant human IGF-2 on eye growth and form-deprivation in guinea pig.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Zhi-hong DengJian-tao Wang

Abstract

By investigating the effects of recombinant human IGF-2 (rhIGF-2) on the diopter, axial eye length and the expression of IGF-2 in non-form-deprivation (FD) and FD eyes of guinea pig, we tried to elucidate the relationship between the effects of rhIGF-2 on eye growth and FD in guinea pig. Eighty 3-week-old guinea pigs were included in the study, which were divided into two groups randomly. Group A (n = 40) was the non-FD group, Thirty-two guinea pigs received intravitreal injections of either 1 ng, 10 ng, 100 ng rhIGF-2 or bovine serum albumin (BSA) to the right eye; eight guinea pigs who received no intravitreal injections served as control. Group B (n = 40) was the FD group; the right eyes were form-deprived, and received the same disposals as group A. The diopter and the axial eye length of all guinea pigs were measured at day 14. The expression of IGF-2 in the retina was measured by Western blot. After 14 days, FD eyes were high myopia. The axial length of FD eyes was significant for longer than that of non-FD eyes. The expression of IGF-2 in the retina of FD eyes was up-regulated. In non-FD group, there was no significant difference in the diopter and axial eye length among rhIGF-2 injection eyes, BSA injection eyes and con...Continue Reading

References

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Aug 18, 2004·Neuron·Josh Wallman, Jonathan Winawer
Dec 3, 2008·Experimental Eye Research·Andrew Ian JoblingNeville Anthony McBrien

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Citations

Apr 30, 2015·Oxidative Medicine and Cellular Longevity·Bosch-Morell FranciscoNavea Amparo
Apr 12, 2016·Medical Hypotheses·Virgilio GalvisJesús Merayo-Lloves
Mar 1, 2019·Investigative Ophthalmology & Visual Science·David TroiloLyndon Jones

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