The correlation of lymphocyte subsets, natural killer cell, and Parkinson's disease: a meta-analysis

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Sen JiangXinling Yang

Abstract

The correlation between immunity and Parkinson's disease was presented in many papers, which also discussed lymphocyte and natural killer cell. But these studies have yielded inconsistent results. To systematically review the relationship between the lymphocyte subsets/natural killer cell and the risk of Parkinson's disease, we electronically searched the SpringerLink, Web of Science, Ebsco-medline with full text, Pubmed, Elsevier-ScienceDirect, Ovid-lww-oup, Wanfang Data for case-control trials on comparing the number of peripheral blood lymphocyte subsets and natural killer cell in Parkinson's patients and healthy controls. According to the Cochrane methods, the reviewers selected literature, extracted data, and assessed the quality. Then, a meta-analysis was performed using RevMan 5.2. Finally, 21 case-control trials including 943 cases of Parkinson's disease were fit into our data analysis. Meta-analysis showed that the decreased numbers of CD3+, CD4+ lymphocyte subsets and the increased number of natural killer cell were found in Parkinson's disease patients. In the intermediate and late stage of PD, CD8+ lymphocyte subsets had a significant decrement. However, the number of B lymphocyte subsets had no significant associat...Continue Reading

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Citations

Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
Jul 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kirsten M AndersonJill A Hollenbach
Apr 4, 2019·Frontiers in Neurology·Marie Therese Fuzzati-ArmenteroFabio Blandini
Sep 26, 2020·Experimental & Molecular Medicine·Rachael H Earls, Jae-Kyung Lee
May 3, 2018·Journal of Neuroinflammation·Megan F DuffyCaryl E Sortwell
Feb 15, 2019·International Journal of Molecular Sciences·Carmen VidaMónica De la Fuente
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Chanond A NasamranPaula Desplats
Nov 14, 2020·International Journal of Molecular Sciences·Chrysoula MarogianniGeorgia Xiromerisiou
May 18, 2021·Frontiers in Aging Neuroscience·Xueping ChenHuifang Shang
Jun 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Laura Muñoz-DelgadoPablo Mir
Jun 29, 2021·Frontiers in Immunology·Austin P PassaroSteven L Stice
Jul 25, 2021·Neurology. Neuroimmunology and Neuroinflammation·Zhaoqi YanHongwei Qin
Mar 12, 2021·Brain : a Journal of Neurology·Gregory P WilliamsAshley S Harms
Oct 15, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Kazuto TsukitaRyosuke Takahashi
Mar 10, 2020·Complementary Therapies in Medicine·Efthalia AngelopoulouAnastasia Bougea

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