The correlation of p22phox and chemosensitivity in EGFR-TKI resistant lung adenocarcinoma

Oncotarget
Masayuki KobayashiHironobu Sasano

Abstract

Enhancing the chemosensitivity in the patients with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistant lung adenocarcinoma (LUAD) is pivotal in achieving their successful therapeutic outcome. We aimed to explore the mechanisms regarding the development of therapeutic resistance to chemotherapy in EGFR-TKI resistant LUAD. Methods: Microarray analysis lead to potential involvement of p22phox, which was abundantly expressed in the cell lines harboring EGFR-TKI resistance and chemoresistance, and was known to regulate several important chemoresistance-associated factors such as hypoxia inducible factor-1α (HIF-1α) and epithelial-mesenchymal transition (EMT). We compared the status of p22phox with that of chemoresistance, HIF-1α expression and EMT in LUAD cell lines. We immunolocalized p22phox in the specimens of lung cancer patients. p22phox and HIF-1α mRNAs were significantly elevated in the cells harboring EMT and chemoresistance. p22phox knockdown enhanced chemosensitivity and reduced the expression of HIF-1α and EMT-associated factors. HIF-1α knockdown enhanced the chemosensitivity, while HIF-1α transfection induced EMT and chemoresistance in these cell lines. All LUAD patients with T790M mutation w...Continue Reading

References

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Jan 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuankai ShiPan-Chyr Yang
Feb 18, 2015·Oncotarget·Chih-Chang HungJeff Yi-Fu Chen
Apr 30, 2015·The New England Journal of Medicine·Pasi A JänneMalcolm Ranson

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Citations

Jul 25, 2021·Cancers·Julien AncelValérian Dormoy

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Methods Mentioned

BETA
Feature Extraction
PCR
Assay

Software Mentioned

Feature Extraction
JMP Pro
Genespring GX11

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