The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis

BMC Infectious Diseases
Xiao MaPeiyun Liu

Abstract

Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language. Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group. The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals.

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Citations

Jun 19, 2021·Acta Parasitologica·Chuanchuan LiuRi-Li Ge
Jun 24, 2021·Seminars in Liver Disease·Solange Bresson-HadniFrançois Chappuis
Nov 13, 2021·Human Vaccines & Immunotherapeutics·Andreon Santos Machado da SilvaPaulo Renato Zuquim Antas

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
fluorescence-activated cell sorting
PCR
biopsy
flow cytometry
PCA

Software Mentioned

R
Cytoscape
vegan
Hmisc
GeneNet
stats

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