The correlations between the expression of FGFR4 protein and clinicopathological parameters as well as prognosis of gastric cancer patients

Journal of Surgical Oncology
Yanwei YeYingqiang Shi

Abstract

Fibroblast growth factor receptor 4 (FGFR4) was seldom investigated in gastric cancer (GC). The purpose of the study was to elucidate the expression of FGFR4 protein in GC and related clinical significance. Ninety-four paraffin-embedded tumor specimens were obtained from Cancer Hospital, Fudan University. The expression of FGFR4 as well as p53, p21, EGFR, neu, c-myc, and PCNA were detected by immunohistochemical method. Then, correlation analysis and survival analysis were performed. The expression rate of FGFR4 protein in GC tissues and normal stomach tissues was 93.6% and 30.8%, respectively (P = 0.000). The expression of FGFR4 was positively correlated with the expression of p21, neu and PCNA (P-value was 0.009, 0.012, and 0.018, respectively). Subgroup analysis showed that compared to low expression group, the prognosis of patients with III/IV stage and negative expression of p21 in high expression group of FGFR4 were worse (P = 0.048, 0.041, respectively). Multivariate analysis showed that TNM stage was the independent prognostic factor in high expression group (HR, 11.593; 95% CI, 3.532-18.058; P = 0.000). High expression of FGFR4 protein, accelerating the progression of advanced GC, might be associated with a poor progno...Continue Reading

References

Nov 1, 1994·International Journal of Cancer. Journal International Du Cancer·J JacquemierD Birnbaum
Dec 1, 1994·International Journal of Cancer. Journal International Du Cancer·H Y LeungN R Lemoine
Apr 20, 1999·Biochemical and Biophysical Research Communications·A TakahashiT Tsukamoto
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Oct 11, 2002·The New England Journal of Medicine·Sebastian Suerbaum, Pierre Michetti
Mar 6, 2003·Human Mutation·C M Fenoglio-PreiserA Noffsinger
Sep 16, 2003·The Kurume Medical Journal·Keishiro AoyagiKazuo Shirouzu
Jan 13, 2004·World Journal of Gastroenterology : WJG·Hao ZhangYuan-Hui Luo
Apr 8, 2004·World Journal of Gastroenterology : WJG·Hai-Long XieYi-Qin Li
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jianghua WangMichael Ittmann
May 3, 2005·Cytokine & Growth Factor Reviews·V P EswarakumarJ Schlessinger
Jul 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christoph ThussbasNadia Harbeck
Jul 27, 2006·Digestive Diseases and Sciences·Dong Il ParkAntonia R Sepulveda
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yasushi SumiyoshiYoshihiko Maehara
Sep 12, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amalia MilanoFatima Cardoso
Feb 27, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H-C KwonH-J Kim
Dec 6, 2008·Digestive Diseases and Sciences·Gregory KouraklisAlkiviadis Kostakis

❮ Previous
Next ❯

Citations

Aug 1, 2013·World Journal of Gastroenterology : WJG·Yan-Ying ShenXing-Zhi Ni
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jingjing LiQuancheng Kan
Oct 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanwei YeQuancheng Kan
May 23, 2015·Gastroenterology Research and Practice·Mikito InokuchiKazuyuki Kojima
Jan 7, 2017·World Journal of Surgical Oncology·Mikito InokuchiKazuyuki Kojima
Feb 17, 2015·World Journal of Gastroenterology : WJG·Hao ChenXing-Zhi Ni
Feb 3, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mustafa YildirimHakan Bozcuk
Jun 7, 2019·Cells·Aroosha RajaSung-Min Ahn
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad AbbasChen Dingding
Aug 26, 2021·The Korean Journal of Internal Medicine·Seonhoo KimWoo Chul Chung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Wei XuJianqing Wu
International Journal of Cancer. Journal International Du Cancer
D C TomlinsonV Speirs
© 2021 Meta ULC. All rights reserved