Aug 1, 1989

The corticotropin-releasing hormone test in patients with posttraumatic stress disorder

Biological Psychiatry
M A SmithC B Nemeroff


To evaluate the hypothalamic-pituitary-adrenal (HPA) axis in patients with posttraumatic stress disorder (PTSD), we measured adrenocorticotropin hormone (ACTH) and cortisol responses following administration of corticotropin-releasing hormone (CRH) in 8 combat veterans with chronic PTSD. The PTSD patients had a significantly lower ACTH response to CRH compared to a control group of normal volunteers. Blunted ACTH responses occurred in patients with PTSD alone, as well as those PTSD patients who also had major depression. The cortisol response, although reduced, was not significantly different from normal. The blunted ACTH response to CRH in PTSD patients is similar to that seen in other psychiatric disorders, such as depression, panic disorder, and anorexia nervosa.

Mentioned in this Paper

POMC wt Allele
Pituitary Diseases
Post-Traumatic Stress Disorder
Fetishism (Psychiatric)
Adrenal Glands
Pituitary Hormonal Agents
Panic Disorder 1
Psychiatry Specialty
Delayed Onset Post-Traumatic Stress Disorder

About this Paper

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