The cortisol awakening response is related with PERIOD1 clock gene expression in older women

Experimental Gerontology
Denise Olbrich, Manuela Dittmar

Abstract

The cortisol awakening response (CAR) is a useful endocrine marker for the hypothalamic-pituitary-adrenal axis activity. Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms. This study aimed to analyze the relationship between CAR and hPER1 gene expression with respect to human aging. Salivary cortisol levels were determined in 20 older women (mean age ± SD, 67.9 ± 5.12 yrs) and 30 young women (24.4 ± 2.13 yrs) at awakening (T0) and at 15 min, 30 min, 45 min, and 60 min after awakening (T15, T30, T45, T60) by enzyme linked immunosorbent assay. CAR was calculated as difference of the cortisol levels at T0 and T30. The expression of the hPER1 gene at 0800 h was determined from oral mucosa cells by relative quantification using h36B4 as house-keeping gene. Additional variables, which may affect the CAR, were assessed by questionnaire. Relationships between CAR and other variables were analyzed by correlation and regression analyses. Older women showed significantly lower mean cortisol levels than young women at all five time points (P < 0.05 to P < 0.01). The cortisol levels at T30, T45, and T60 correlated positively and signific...Continue Reading

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Citations

Mar 1, 2014·Acta Biochimica Et Biophysica Sinica·Xiyan ZhaoYuhui Wang
Oct 1, 2013·Metabolism: Clinical and Experimental·Animesh SharmaJohannes D Veldhuis
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Jul 31, 2018·Asian-Australasian Journal of Animal Sciences·Melody DzvitiVoster Muchenje
Apr 11, 2018·American Journal of Physiology. Endocrinology and Metabolism·Kathleen M GavinWendy M Kohrt

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