The cost-benefit of federal investment in preventing Clostridium difficile infections through the use of a multifaceted infection control and antimicrobial stewardship program

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Rachel B SlaytonJohn A Jernigan

Abstract

To determine the potential epidemiologic and economic value of the implementation of a multifaceted Clostridium difficile infection (CDI) control program at US acute care hospitals Markov model with a 5-year time horizon Patients whose data were used in our simulations were limited to hospitalized Medicare beneficiaries ≥65 years old. CDI is an important public health problem with substantial associated morbidity, mortality, and cost. Multifaceted national prevention efforts in the United Kingdom, including antimicrobial stewardship, patient isolation, hand hygiene, environmental cleaning and disinfection, and audit, resulted in a 59% reduction in CDI cases reported from 2008 to 2012. Our analysis was conducted from the federal perspective. The intervention we modeled included the following components: antimicrobial stewardship utilizing the Antimicrobial Use and Resistance module of the National Healthcare Safety Network (NHSN), use of contact precautions, and enhanced environmental cleaning. We parameterized our model using data from CDC surveillance systems, the AHRQ Healthcare Cost and Utilization Project, and literature reviews. To address uncertainty in our parameter estimates, we conducted sensitivity analyses for interv...Continue Reading

Associated Clinical Trials

Nov 1, 2016·José María Aguado García, MD, PhD, José María Aguado García, MD, PhD

References

Mar 27, 2002·International Journal of Health Services : Planning, Administration, Evaluation·Isaac ShapiroWendell Primus
Jun 11, 2004·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Laura A PuzniakLinda M Mundy
Aug 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis ValiquetteJacques Pépin
Feb 7, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert C OwensCarlene A Muto
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Sep 28, 2010·Journal of Infection and Public Health·Gracia FellmethShabnam Iyer
Jun 10, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R DubberkeUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Jun 15, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S M McGloneB Y Lee
Nov 8, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Hannah R PalmerKevin W Garey
Mar 16, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·UNKNOWN Society for Healthcare Epidemiology of AmericaUNKNOWN Pediatric Infectious Diseases Society
Mar 16, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Harold C StandifordGraeme N Forrest
Mar 16, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·James R BeardsleyChristopher C Ohl
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fernanda C LessaL Clifford McDonald
Jul 7, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erik R Dubberke, Margaret A Olsen
Oct 2, 2012·The Journal of Antimicrobial Chemotherapy·Diane Ashiru-OredopeUNKNOWN ARHAI Antimicrobial Stewardship Group
Dec 12, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dawn M SievertUNKNOWN National Healthcare Safety Network (NHSN) Team and Participating NHSN Facilities
Jan 8, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kate Traynor
May 9, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Anna C SickAllison L Agwu
Mar 11, 2015·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Ying P TabakL Clifford McDonald

❮ Previous
Next ❯

Citations

Oct 22, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Marci DreesGrace M Lee
Mar 30, 2017·Expert Review of Gastroenterology & Hepatology·Lynne V McFarland
Mar 1, 2019·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·R Douglas ScottKimberly J Rask
Nov 28, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Preeti MehrotraThomas J Sandora
Feb 26, 2019·Antimicrobial Resistance and Infection Control·Dilip NathwaniClaudie Charbonneau
Aug 31, 2015·GE Portuguese Journal of Gastroenterology·Joana CarmoCristina Chagas
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·John TamRoman A Melnyk
Jul 11, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Elena ReigadasUNKNOWN European Society of Clinical Microbiology and Infectious Diseases Study Group on Clostridioides difficile (ESGCD) and Study
Jun 24, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N R NaylorJ V Robotham

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Sanjay SaintM Todd Greene
Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine
Erik R Dubberke
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Monika Pogorzelska-MaziarzPatricia W Stone
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Larry K KociolekDale N Gerding
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Timothy C JenkinsPhilip S Mehler
© 2021 Meta ULC. All rights reserved