The cost effectiveness of ACE inhibitors as first-line antihypertensive therapy

PharmacoEconomics
Alain J NordmannAllan S Detsky

Abstract

Current hypertension guidelines differ in their recommendations for first-line antihypertensive therapy. To evaluate the cost effectiveness of ACE inhibitor therapy as antihypertensive first-line therapy as compared with conventional antihypertensive therapy with beta-adrenoceptor antagonists or diuretics. Cost-effectiveness analysis based on data from randomised trials and observational studies comparing the effectiveness of ACE inhibitor and conventional antihypertensive therapy, we constructed a Markov model to compare four strategies in the management of uncomplicated hypertension: (i) prescribing ACE inhibitor therapy to all patients; (ii) prescribing conventional therapy to all patients; (iii) individualised antihypertensive therapy based on the presence or absence of left ventricular hypertrophy on electrocardiography (ECG); or (iv) individualised antihypertensive therapy based on the presence or absence of left ventricular hypertrophy on echocardiography. Cost data were derived from the medical literature and focus groups, and utility values were derived from patients on antihypertensive monotherapy. All costs were calculated in 1999 Canadian dollars, but are reported in US dollars according to the 1999 purchasing power...Continue Reading

References

Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Apr 15, 1987·The American Journal of Cardiology·D LevyW P Castelli
Dec 14, 1987·The American Journal of Cardiology·W B KannelD Levy
Sep 26, 1983·The American Journal of Medicine·W B Kannel
May 1, 1982·Stroke; a Journal of Cerebral Circulation·R L SaccoP M McNamara
Oct 1, 1994·The American Journal of Cardiology·G SchillaciC Porcellati
Apr 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D G FrybackP A Martin
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·M S DennisC P Warlow
May 22, 1996·JAMA : the Journal of the American Medical Association·D LevyK K Ho
Jan 1, 1996·European Heart Journal·J TingleffM Kirchoff
Sep 1, 1996·Stroke; a Journal of Cerebral Circulation·T N TaylorM F Jacobson
Dec 1, 1996·Journal of the American College of Cardiology·K F AdamsG Koch
Apr 1, 1997·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D NaimarkA S Detsky
Apr 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R E SchmiederP Martus
May 30, 1998·The American Journal of Cardiology·M W RussellS C Hartz
Feb 19, 1999·Lancet
Apr 6, 1999·The American Journal of Cardiology·T E DeleaG Oster
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
May 12, 2000·Journal of the American College of Cardiology·J S GottdienerR C Boineau
Jun 14, 2000·European Heart Journal·F C LampeS Ebrahim
Aug 30, 2001·Archives of Internal Medicine·C BourgaultS Suissa
Jun 13, 2002·Current Hypertension Reports·Norman K Hollenberg
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Feb 14, 2003·The New England Journal of Medicine·Lindon M H WingUNKNOWN Second Australian National Blood Pressure Study Group

❮ Previous
Next ❯

Citations

May 1, 2008·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Manouchehr TavakoliRonald Macwalter
Apr 29, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francisco LeyvaJohn Morgan
Apr 10, 2010·Central European Journal of Public Health·Anna D Ivanova, Guenka I Petrova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.