The cost-effectiveness of organ preservation methods in renal transplantation: US projections based on the machine preservation trial

Transplantation Proceedings
Susan S GarfieldR W Evans

Abstract

The European Machine Preservation Trial (MPT) found a significantly lower rate of delayed graft function and improved graft survival in machine-perfused kidneys compared to cold-stored kidneys in the first year following kidney transplantation. Little is known about the cost-effectiveness of various organ preservation methods. Outcome data from the MPT have been used to conduct a comparative cost-effectiveness analysis based on preservation method for both standard criteria (SCD) and expanded criteria donor (ECD) kidney transplants in the United States. Using graft survival as the primary outcome measure, a cost-effectiveness model was developed using Medicare and private payer cost/payment data, as well as clinical transition probabilities based on the MPT and other studies. At 1-year posttransplant, machine perfusion is a more cost-effective option than cold storage for organ preservation in transplants involving either SCD ($92,561 vs $104,118) or ECD ($106,012 vs $114,530) kidneys. Moreover, the cost-effectiveness ratios for transplants involving machine-perfused ECD kidneys ($106,012) are similar to those for transplants using cold-stored SCD kidneys ($104,118). Machine perfusion is preferable to cold storage for organ pre...Continue Reading

References

Sep 28, 1989·The New England Journal of Medicine·A Leaf
Feb 28, 1985·The New England Journal of Medicine·R W EvansE G Lowrie
Mar 2, 2005·International Journal of Technology Assessment in Health Care·Juan G Gonzalez-PerezSarah Wordsworth
Nov 15, 2005·Health Affairs·James C Robinson
Oct 27, 2006·The New England Journal of Medicine·M Gregg Bloche
May 8, 2007·Journal of the American College of Surgeons·Robert J StrattaPatricia L Adams
Aug 30, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julio PascualJohn D Pirsch
Oct 18, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P M BuchananP R Salvalaggio
Jan 2, 2009·The New England Journal of Medicine·Cyril MoersRutger J Ploeg
Apr 4, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J E Tuttle-NewhallR S Sung
May 8, 2009·The New England Journal of Medicine·Alan M Garber, Sean R Tunis
May 8, 2009·The New England Journal of Medicine·Jerry Avorn
May 8, 2009·The New England Journal of Medicine·Aanand D Naik, Laura A Petersen

❮ Previous
Next ❯

Citations

Mar 26, 2013·Journal of the American College of Surgeons·Robert M CannonGlen A Franklin
Jan 27, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Leo Roels, Axel Rahmel
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P L TsoM L Henry
Sep 8, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Susan S Garfield, Roger W Evans
Mar 16, 2019·The Cochrane Database of Systematic Reviews·Samuel J TingleColin H Wilson
Jun 10, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yohann FoucherUNKNOWN DIVAT Consortium
Dec 4, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Shih-Chieh Jeff ChuehEdwin J Avallone
Dec 17, 2010·Annals of Biomedical Engineering·B M DoorschodtR H Tolba
Apr 27, 2021·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Raquel Martins E QuininoElias David-Neto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
P M BuchananP R Salvalaggio
Source Code for Biology and Medicine
Zoran BursacDavid W Hosmer
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jesse D ScholdHerwig-Ulf Meier-Kriesche
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
L MatsuokaR Selby
© 2022 Meta ULC. All rights reserved