The cost of inbreeding in Arabidopsis

Nature
Carlos BustamanteDaniel L Hartl

Abstract

Population geneticists have long sought to estimate the distribution of selection intensities among genes of diverse function across the genome. Only recently have DNA sequencing and analytical techniques converged to make this possible. Important advances have come from comparing genetic variation within species (polymorphism) with fixed differences between species (divergence). These approaches have been used to examine individual genes for evidence of selection. Here we use the fact that the time since species divergence allows combination of data across genes. In a comparison of amino-acid replacements among species of the mustard weed Arabidopsis with those among species of the fruitfly Drosophila, we find evidence for predominantly beneficial gene substitutions in Drosophila but predominantly detrimental substitutions in Arabidopsis. We attribute this difference to the Arabidopsis mating system of partial self-fertilization, which corroborates a prediction of population genetics theory that species with a high frequency of inbreeding are less efficient in eliminating deleterious mutations owing to their reduced effective population size.

Citations

Jul 17, 2008·Journal of Molecular Evolution·Akihiro FujimotoHidenori Tachida
Sep 27, 2008·Journal of Molecular Evolution·John J WelchDavid Waxman
Apr 10, 2003·Trends in Genetics : TIG·Timothy H Bestor
Nov 16, 2002·Current Opinion in Genetics & Development·Christian Schlötterer
Nov 1, 2011·Nature Chemical Biology·Jason MillerSteven Finkbeiner
Mar 9, 2006·European Journal of Human Genetics : EJHG·Justin Fay
Sep 13, 2007·Heredity·M Anisimova, D A Liberles
May 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Philipp W Messer, Dmitri A Petrov
Jul 14, 2010·Genome Biology and Evolution·James J Cai, Dmitri A Petrov
Jun 28, 2011·Genome Biology and Evolution·Jeffrey D Jensen, Doris Bachtrog
Sep 20, 2011·Genome Biology and Evolution·Tanja SlotteMikkel H Schierup
Feb 22, 2012·Genome Biology and Evolution·M M PentonyM D Purugganan
May 23, 2013·Genome Biology and Evolution·Andrea PorcedduSalvatore Camiolo
Jan 16, 2008·Molecular Biology and Evolution·Jane Charlesworth, Adam Eyre-Walker
Apr 9, 2008·Molecular Biology and Evolution·John Paul FoxeStephen I Wright
Jun 3, 2008·Molecular Biology and Evolution·G A Babbitt, Y Kim
Aug 1, 2008·Molecular Biology and Evolution·Austin L HughesJeffrey O French
Nov 27, 2008·Molecular Biology and Evolution·Josefa GonzálezDmitri A Petrov
Jul 25, 2009·Molecular Biology and Evolution·Jonathan M FlowersMichael D Purugganan
Mar 20, 2010·Molecular Biology and Evolution·Toni I GossmannAdam Eyre-Walker
Oct 19, 2010·Molecular Biology and Evolution·Jared L StrasburgLoren H Rieseberg
Mar 19, 2011·Molecular Biology and Evolution·Samir BhattOliver G Pybus
Jun 11, 2011·Molecular Biology and Evolution·Simona FornarinoLluis Quintana-Murci
Nov 22, 2011·Molecular Biology and Evolution·Sarah S Saminadin-PeterJohn Parsch
Jan 19, 2013·Molecular Biology and Evolution·Jeffrey M GoodSvante Pääbo
Feb 7, 2013·Molecular Biology and Evolution·Ilan GronauAdam Siepel
Nov 26, 2002·Molecular Biology and Evolution·Adam Eyre-WalkerDaniel Gaffney
Aug 30, 2002·Molecular Biology and Evolution·Stephen I WrightDeborah Charlesworth
Oct 4, 2006·Proceedings. Biological Sciences·Sylvain GléminDeborah Charlesworth
Feb 11, 2009·Proceedings. Biological Sciences·Maurine Neiman, Douglas R Taylor
Jul 2, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David E Carr, Michele R Dudash
Jul 2, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Deborah Charlesworth
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J J Emerson, Wen-Hsiung Li
May 7, 2010·Genome Research·J J EmersonWen-Hsiung Li
Dec 13, 2005·Genome Research·John P PollingerRobert K Wayne

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