The cost utility of bupropion in smoking cessation health programs: simulation model results for Sweden

Chest
Kristian BolinStefan Willers

Abstract

To calculate incremental cost-utility ratios (cost per quality-adjusted life-year [QALY] gained) for bupropion (Zyban; GlaxoSmithKline; Gothenburg, Sweden), as compared to nicotine replacement therapy (NRT) in smoking cessation programs for a follow-up period of 20 years. The Global Health Outcomes simulation model was used for a male cohort and for a female cohort as a point of departure but was further extended in order to include the following: (1) the indirect effects of smoking cessation on production and consumption in the economy, and (2) morbidity-specific QALYs gained. Sweden in 2001. Model cohort consisting of 612,851 male and 780,970 female smokers, distributed by age, > or = 35 years old, as in the Swedish population of 2001. Bupropion, as compared to NRT (nicotine patches and nicotine gums), in smoking cessation programs for a follow-up period of 20 years. When the indirect effects on production and consumption were taken into account, bupropion was cost saving in comparison to both NRTs. When only the direct costs were included, bupropion was still cost saving in comparison to nicotine gum. The incremental costs per QALY gained were relatively low for bupropion in comparison to nicotine patches, 6,600 Swedish kron...Continue Reading

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Jun 9, 2009·Journal of Behavioral Medicine·Shannon Gravely-WitteSherry L Grace
Jul 5, 2012·The Nurse Practitioner·Kelly Bosak
Apr 10, 2009·PharmacoEconomics·Ataru IgarashiKiichiro Tsutani
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