The cost-utility of rotavirus vaccination with Rotarix (RIX4414) in the Netherlands

Vaccine
Lucas M A GoossensMaiwenn J Al

Abstract

The objective of this study was to estimate the cost-utility of mass vaccination of 0-4-year-old children with Rotarix in the Netherlands. We used a Markov process with Dutch data on incidence, resource use and costs (GP, hospitalisation, productivity loss and household costs) to compare vaccination to conventional treatment from a societal perspective. Utility loss due to rotavirus-induced diarrhoea was measured using EQ5D, with GPs and paediatricians serving as proxies to fill out the questions. As the costs of a vaccination course ranged from 90 euro to 100 euro per child, the cost-utility ratio varied from 21,900 euro to 35,076 euro per QALY gained. Based on the current study, it is clear that mass vaccination with Rotarix against rotavirus gastroenteritis can be attractive, from an economic and a health care perspective.

References

Sep 1, 1994·Health Economics·B A van HoutF F Rutten
Oct 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·F A Sonnenberg, J R Beck
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A de WitY T van Duynhoven
Mar 10, 2001·Reviews in Medical Virology·S M FeinstoneP V Holland
Jul 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A de WitY T van Duynhoven
Oct 3, 2001·American Journal of Epidemiology·M A de WitY T van Duynhoven
Jan 29, 2002·Epidemiology and Infection·M A de WitY T van Duynhoven
Dec 18, 2002·PharmacoEconomics·Nancy ThiryEddy Van Doorslaer
May 20, 2003·PharmacoEconomics·Christa Claes, Johann-Matthias Graf von der Schulenburg
Apr 6, 2004·Epidemiology and Infection·W E van den BrandhofY T H P van Duynhoven
Apr 21, 2004·International Journal of Technology Assessment in Health Care·Rianne OostenbrinkHenriëtte A Moll
Jul 24, 2004·BMJ : British Medical Journal·Michael D Rawlins, Anthony J Culyer
Mar 2, 2005·International Journal of Technology Assessment in Health Care·Cynthia P IglesiasUNKNOWN NEVALAT Project Group
May 10, 2005·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Laurent CoudevilleBenoit Dervaux
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
Mar 28, 2007·The Journal of Infectious Diseases·Pierre Van DammeUNKNOWN REVEAL Study Group
Apr 4, 2007·Pediatrics·Marc-Alain WiddowsonRoger I Glass
Aug 25, 2007·BMJ : British Medical Journal·John ApplebyDavid Parkin

❮ Previous
Next ❯

Citations

Feb 25, 2014·Vaccine·Pamela AidelsburgerOle Wichmann
Jan 23, 2009·BMC Public Health·Sun-Young KimJoshua A Salomon
Jun 15, 2011·BMC Public Health·Mark H RozenbaumUNKNOWN Consensus Group on Dutch Rotavirus Vaccination (CoRoVa-Group)
Jul 26, 2012·The Pediatric Infectious Disease Journal·Patricia Bruijning-VerhagenMarc J M Bonten
Dec 24, 2009·Epidemiology and Infection·T Van EffelterreJ Gray
Nov 20, 2013·Health Economics Review·Stefanie KnollBaudouin Standaert
Aug 8, 2013·Journal of Medical Economics·Robbin ItzlerPraveen Dhankhar
Nov 15, 2011·Academic Pediatrics·S Maria E FinnellStephen M Downs
Mar 30, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michael HerdmanNancy Devlin
May 18, 2010·Vaccine·Carlos RodrigoCarlo Giaquinto
May 16, 2009·The Journal of Allergy and Clinical Immunology·Stephan von GuntenBruce S Bochner
Aug 26, 2015·Vaccine·Sebastián García MartíJorge Gomez
Sep 24, 2015·Iranian Journal of Pediatrics·Sareh ShakerianMohsen Yaghoubi
Aug 26, 2011·Vaccine·A Brett HauberEmmanuel B Walter
Apr 11, 2013·Human Vaccines & Immunotherapeutics·Samuel AballéaMondher Toumi
May 28, 2014·Human Vaccines & Immunotherapeutics·Richard RheingansJacob Atem
Dec 14, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·J Noyes, R T Edwards
Jun 6, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Richard J Milne, Keith Grimwood
Aug 24, 2010·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Sun-Young KimJoshua A Salomon
Dec 3, 2014·Environmental Health Insights·Guy Hutton, Bettina Menne
Nov 23, 2019·Expert Review of Pharmacoeconomics & Outcomes Research·Nikolaos KotsopoulosBaudouin Standaert
Jan 1, 2008·Applied Health Economics and Health Policy·Baudouin StandaertBruno Detournay
Jan 1, 2008·Journal of Medical Economics·Alan MartinBaudouin Standaert
Oct 24, 2018·Applied Health Economics and Health Policy·Tara A LavellePei-Jung Lin
Oct 21, 2016·Human Vaccines & Immunotherapeutics·Shu-Ling HoshiIchiro Okubo
Jun 15, 2019·Infectious Diseases and Therapy·Surasak SaokaewChrista Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.