PMID: 2858239Feb 1, 1985Paper

The costo-uterine muscle of the rat contains a homogeneous population of beta-adrenoceptors

British Journal of Pharmacology
M L Hartley, J N Pennefather

Abstract

The effects of two selective beta-adrenoceptor antagonists on the inhibitory responses to some sympathomimetic amines of electrically-stimulated preparations of costo-uterine muscle, taken from virgin rats, have been examined quantitatively. pA2 values for the antagonist, atenolol (beta 1-selective) and ICI 118,551 (beta 2-selective) were obtained using as agonists, fenoterol (beta 2-selective agonist) and noradrenaline (alpha- and beta-adrenoceptor agonist, beta 1-selective); and in addition, with ICI 118,551 only, isoprenaline (beta-agonist, non-selective) and adrenaline (alpha- and beta-adrenoceptor agonist, beta 2-selective). Catecholamine uptake mechanisms and alpha-adrenoceptors were not blocked in any of these experiments. Atenolol competitively antagonized the effects of fenoterol and noradrenaline to a similar extent, the pA2 values being 5.4 and 5.7, respectively. ICI 118,551 competitively antagonized the effects of fenoterol, isoprenaline, adrenaline and noradrenaline to a similar extent; pA2 values ranged from 8.7 with noradrenaline to 9.1 with isoprenaline. These results extend our previous observations which indicated that the adrenoceptors mediating inhibition of electrically-evoked contractions of costo-uterine ...Continue Reading

References

Nov 15, 1978·European Journal of Pharmacology·C RaperD Iakovidis
Jul 11, 1970·The American Journal of Physiology·C E Melton, J T Saldivar
Apr 1, 1980·British Journal of Pharmacology·D IakovidisC Raper
Sep 1, 1981·Journal of Autonomic Pharmacology·S R O'Donnell, J C Wanstall
Jan 1, 1980·The Anatomical Record·I E Lawrence, H W Burden

Citations

Jul 1, 1987·Clinical and Experimental Pharmacology & Physiology·J N PennefatherJ A Leedham
Jul 1, 1989·Clinical and Experimental Pharmacology & Physiology·D FoxJ N Pennefather
May 27, 2008·British Journal of Pharmacology·E DavisR J Summers
May 1, 1989·The Journal of Pharmacy and Pharmacology·M L Candenas, E Anselmi
Jul 17, 2007·European Journal of Pharmacology·Angela K ClouseTimothy D Westfall
Jun 1, 1987·Journal of Autonomic Pharmacology·C J CookM E Story
Jul 1, 1986·British Journal of Pharmacology·G A Bentley, J Starr

Related Concepts

1-(3,4-dimethoxyphenethylamino)-3-(3,4-dihydroxyphenoxy)-2-propanol
ICI 118551, hydrochloride
Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Tenormin
Catechols
Electric Stimulation Technique
Medihaler-Epi
Fenoterol Hydrobromide
Novodrin

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