PMID: 8597581Feb 16, 1996Paper

The counterion influence on cationic lipid-mediated transfection of plasmid DNA

Biochimica Et Biophysica Acta
A M AberleM H Nantz

Abstract

A panel of DOTAP analogs was prepared by altering the anionic counterion that accompanies the trimethylammonium polar domain. The transfection of plasmid DNA into NIH3T3 cells and mouse lung was examined using the counterion analogs. The in vitro transfection activity decreased as follows: DOTAP.bisulfate > trifluoromethanesulfonate approximately equal to iodide approximately equal to bromide > dihydrogenphosphate approximately equal to chloride approximately equal to acetate > sulfate. A similar activity trend was observed in vivo.

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·J Mönkkönen, A Urtti
Apr 7, 2012·European Journal of Medicinal Chemistry·Haigang ChenXin Guo
Jun 28, 2011·Trends in Biotechnology·Nilesh P IngleTheresa M Reineke
Oct 19, 2004·International Journal of Pharmaceutics·Saâdia AsgatayMarie Pierre Rols
Nov 5, 1999·Biophysical Journal·R C MacDonaldT J McIntosh
Sep 29, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Anna L David, Donald Peebles
Nov 26, 1998·Human Gene Therapy·C Guillaume-GableC Férec
Dec 28, 1999·Human Gene Therapy·K SchughartH V Kolbe
May 21, 2010·Bioconjugate Chemistry·Claire CeballosMichel Camplo
Apr 29, 1998·Biochimica Et Biophysica Acta·K KarikóD J Langer
Apr 11, 2000·Journal of Pharmaceutical Sciences·P DelépineC Férec

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