Feb 16, 1976

The coupling of beta1-24-corticotropin to the adenylate-cylase system in rat adipocytes. Evidence for hormone-nucleotides interaction (author's transl)

European Journal of Biochemistry
J Pairault

Abstract

The general aim was to define some of the most important parameters involved in the coupling step between the synthetic analog of adrenocoricotropin hormone (beta1-24-corticotropin tetracosa peptide) and the catalytic unit of the adenylate-cyclase system of fat cells. These studies were performed with a purified plasma membrane fraction from rat adipose tissue. In this regard, some effects of ions, pH, and nucleotides (ATP nad GTP) on this hormone sensitive system were studied A simple model based on a random association process of reactants yeilded a statisfactory approximation of the kinetic data. In contract to results obtained by two other groups, which were analyzed by De Haen, no evidence was found for a regulation of the adenylate-cyclase activity by the adenosine triphosphate which was not complexed to magnesium...

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Mentioned in this Paper

Fat Pad
Magnesium Measurement
Calcium
Membrane Fraction
Plasma Protein Binding Capacity
Adenylate
Nucleotides
Recombinant Corticotropin
Adenosine Triphosphate
Adipocytes

About this Paper

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