The course of apathy in late-life depression treated with electroconvulsive therapy; a prospective cohort study

International Journal of Geriatric Psychiatry
A CarlierDidi Rhebergen

Abstract

Apathy, a lack of motivation, is frequently seen in older individuals, with and without depression, with substantial impact on quality of life. This prospective cohort study of patients with severe late-life depression treated with electroconvulsive therapy (ECT) aims to study the course of apathy and the predictive value of vascular burden and in particular white matter hyperintensities on apathy course. Information on apathy (defined by a score of >13 on the Apathy Scale), depression severity, vascular burden, and other putative confounders was collected in at 2 psychiatric hospitals on patients with late-life depression (aged 55 to 87 years, N = 73). MRI data on white matter hyperintensities were available in 52 patients. Possible risk factors for apathy post-ECT were determined using regression analyses. After treatment with ECT, 52.0% (26/50) of the depression remitters still suffered from clinically relevant apathy symptoms. In the entire cohort, more patients remained apathetic (58.9%) than depressed (31.5%). Presence of apathy post-ECT was not associated with higher age, use of benzodiazepines, or severity of apathy and depression at baseline. Less response in depressive symptomatology after ECT predicted post-treatment...Continue Reading

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Citations

Feb 11, 2020·Journal of Geriatric Psychiatry and Neurology·Mardien Leoniek OudegaAnnemieke Dols
May 1, 2020·Journal of the American Geriatrics Society·Anne Suzanne BertensNathaly Rius Ottenheim
Aug 11, 2020·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Sara L Weisenbach

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