The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants

PloS One
Yvan VandenplasKoen Huysentruyt

Abstract

The Cow's Milk-related Symptom Score (CoMiSSTM) was developed as an awareness tool to recognize possible manifestations of cow's milk protein allergy (CMPA). Arbitrarily, a cut-off value of ≥12 was defined as a "positive score." The aim of this study was to determine an age-related CoMiSS in healthy infants to minimize the risk of false reassurance or over-diagnosis of CMPA in case of a negative or positive score, respectively. General pediatricians determined the CoMiSS in presumed healthy infants aged ≤6 months during a routine visit. Exclusion criteria included any known acute or chronic disease, preterm delivery (< 37 weeks), therapeutic formula, any food supplement (except vitamins) or medication. Data from 891 consecutive infants were collected. Complete information was obtained from only 413 (46.4%) infants: Belgium: 31.2%, Italy 18.2%, Poland 19.1% and Spain 31.5%. Since gender (girls vs boys) (p = 0.579) had no influence on the CoMiSS, the data were re-calculated to include those infants with missing gender. The overall median and mean (SD) CoMiSS scores were, respectively, 3.0 and 3.7 (2.9). The 95th percentile was 9. Median crying (p<0.001), regurgitation (p = 0.009) and eczema (p = 0.039) scores differed significant...Continue Reading

References

Sep 27, 2007·Archives of Disease in Childhood·Yvan VandenplasChristophe Dupont
Apr 29, 2009·Acta Paediatrica·Badriul HegarYvan Vandenplas
May 8, 2013·Journal of Pediatric Gastroenterology and Nutrition·Y VandenplasA Bocquet
Oct 15, 2014·The Journal of Allergy and Clinical Immunology·Karen A RobbinsCorinne A Keet
Aug 27, 2015·Journal of Pediatric Gastroenterology and Nutrition·Yvan VandenplasNikhil Thapar
Apr 8, 2017·The Journal of Pediatrics·Dieter WolkeMuthanna Samara
Apr 13, 2017·Pediatric Gastroenterology, Hepatology & Nutrition·Yvan VandenplasRajat Mukherjee

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Citations

Mar 21, 2020·Current Opinion in Allergy and Clinical Immunology·Alessandro Fiocchi, Motohiro Ebisawa
Mar 25, 2020·Pediatric Gastroenterology, Hepatology & Nutrition·Karolina BigorajskaHania Szajewska
Sep 19, 2019·World Journal of Clinical Cases·Danilo RossettiSalvatore Oliva
Apr 30, 2020·Current Opinion in Allergy and Clinical Immunology·Alessandro Fiocchi, Motohiro Ebisawa
May 11, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Georgina ThompsonChristopher Hyde
Jul 29, 2021·Pediatric Gastroenterology, Hepatology & Nutrition·Anna Kozłowska-JalowskaHania Szajewska

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Software Mentioned

CoMiSS
R

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