The crab-eating frog, Rana cancrivora, up-regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity

Journal of Experimental Zoology. Part A, Comparative Experimental Biology
Patricia A WrightYuen Kwong Ip

Abstract

The crab-eating frog Rana cancrivora is one of only a handful of amphibians worldwide that tolerate saline waters. They typically inhabit brackish water of mangrove forests of Southeast Asia, but live happily in freshwater and can be acclimated to 75% seawater (25 ppt) or higher. We report here that after transfer of juvenile R. cancrivora from freshwater (1 ppt) to brackish water (10 -->20 or 20 -->25 ppt; 4-8 d) there was a significant increase in the specific activity of the key hepatic ornithine urea cycle enzyme (OUC), carbamoyl phosphate synthetase I (CPSase I). At 20 ppt, plasma, liver and muscle urea levels increased by 22-, 21-, and 11-fold, respectively. As well, muscle total amino acid levels were significantly elevated by 6-fold, with the largest changes occurring in glycine and beta-alanine levels. In liver, taurine levels were 5-fold higher in frogs acclimated to 20 ppt. There were no significant changes in urea or ammonia excretion rates to the environment. As well, the rate of urea influx (J(in) (urea)) and efflux (J(out) (urea)) across the ventral pelvic skin did not differ between frogs acclimated to 1 versus 20 ppt. Taken together, these findings suggest that acclimation to saline water involves the up-regula...Continue Reading

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Citations

Jul 14, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Serene M L LeeYuen K Ip
Nov 11, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Uditha WijethungaRichard Shine
Jul 11, 2008·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Tamar M SchillerRichard E Lee
Oct 6, 2009·Environmental Pollution·Manuel E Ortiz-SantaliestraAdolfo Marco
Aug 21, 2007·Molecular Immunology·Yi LuRen Lai

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