The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Fernando AguadoEduardo Soriano

Abstract

The family of CREB (cAMP response element-binding protein) transcription factors are involved in a variety of biological processes including the development and plasticity of the nervous system. In the maturing and adult brain, CREB genes are required for activity-dependent processes, including synaptogenesis, refinement of connections and long-term potentiation. Here, we use CREB1(Nescre)CREM(-/-) (cAMP-responsive element modulator) mutants to investigate the role of these genes in stimulus-independent patterns of neural activity at early stages. We show that lack of CREB/CREM genes specifically in neural tissue leads to increased synaptogenesis and to a dramatic increase in the levels of spontaneous network activity at embryonic stages. Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development.

Citations

Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ravi JagasiaD Chichung Lie
Jun 25, 2014·Trends in Pharmacological Sciences·Yan Dong, Eric J Nestler
Jan 24, 2012·Nature Chemical Biology·Jessica E RexachLinda C Hsieh-Wilson
Jan 28, 2015·Neuroscience Letters·Evan J Kyzar, Subhash C Pandey
Jul 30, 2011·Neuroscience Letters·Robyn M Amos-KroohsCharles V Vorhees
Jun 16, 2015·Neural Plasticity·Annabella PignataroSilvia Middei
Sep 25, 2010·PLoS Computational Biology·Mati GoldbergEshel Ben-Jacob
Oct 4, 2011·PloS One·Evangelos Delivopoulos, Alan F Murray
Apr 20, 2004·PLoS Biology·Hajime HiraseGyörgy Buzsáki
Jul 19, 2016·The International Journal of Biochemistry & Cell Biology·Antonio FiorinoDaniela Perotti
Jul 13, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mark E LushLuis F Parada
Apr 26, 2011·Progress in Neurobiology·Alfredo BellonThérèse M Jay
Dec 25, 2004·Brain Research. Developmental Brain Research·Alan P FarwellJack L Leonard
May 21, 2014·Psychiatry Investigation·Alberto ChiesaAlessandro Serretti
Jan 8, 2021·Frontiers in Neuroscience·Joseph R LoverdeBryan J Pfister

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.