The critical role of hemodynamics in the development of cerebral vascular disease

Journal of Neurosurgery
Alexander M NixonBauer E Sumpio

Abstract

Atherosclerosis and intracranial saccular aneurysms predictably localize in areas with complex arterial geometries such as bifurcations and curvatures. These sites are characterized by unique hemodynamic conditions that possibly influence the risk for these disorders. One hemodynamic parameter in particular has emerged as a key regulator of vascular biology--wall shear stress (WSS). Variations in geometry can change the distribution and magnitude of WSS, thus influencing the risk for vascular disorders. Computer simulations conducted using patient-specific data have suggested that departures from normal levels of WSS lead to aneurysm formation and progression. In addition, multiple studies indicate that disturbed flow and low WSS predispose patients to extracranial atherosclerosis, and particularly to carotid artery disease. Conversely, in the case of intracranial atherosclerosis, more studies are needed to provide a firm link between hemodynamics and atherogenesis. The recognition of WSS as an important factor in cerebral vascular disease may help to identify individuals at risk and guide treatment options.

References

Feb 1, 1990·Stroke; a Journal of Cerebral Circulation·M Fisher, S Fieman
Feb 1, 1985·Annals of Surgery·M E DeBakeyD H Glaeser
Jan 1, 1988·Clinical Neurology and Neurosurgery·A de PaepeJ de Reuck
May 1, 1985·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D N KuS Glagov
Nov 1, 1971·The British Journal of Radiology·R G GoslingK W Twinn
Oct 1, 1965·Circulation·C M FisherP D White
Sep 1, 1984·Stroke; a Journal of Cerebral Circulation·K N KayembeF Hazama
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·M Motomiya, T Karino
Apr 1, 1995·Pharmacology & Therapeutics·R M Lee
Jun 1, 1995·The Annals of Thoracic Surgery·M J Thubrikar, F Robicsek
May 1, 1993·The Clinical Investigator·M RiedelP Lichtlen
Aug 1, 1996·Journal of Biomechanics·H W HoogstratenP J Wensing
Feb 1, 1996·Journal of Biomechanical Engineering·C C Rindt, A A Steenhoven
Mar 1, 1996·Journal of Biomechanics·J RavensbergenH W Hoogstraten
Nov 1, 1996·Stroke; a Journal of Cerebral Circulation·R J WitykB Litt
Oct 1, 1996·Current Opinion in Lipidology·P LibbyR T Lee
Feb 1, 1997·Stroke; a Journal of Cerebral Circulation·S KondoH Kataoka
Feb 15, 1997·The Journal of Clinical Investigation·M C LinS Chien
May 1, 1997·Journal of Biomechanical Engineering·J RavensbergenH W Hoogstraten
Apr 1, 1997·Neurological Research·G N FoutrakisR J Sclabassi
Jan 1, 1997·Endothelium : Journal of Endothelial Cell Research·B O OluwoleB E Sumpio
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·S KondoH Kataoka
May 9, 1998·Journal of Molecular and Cellular Cardiology·A G VouyoukaB E Sumpio
May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J RavensbergenH W Hoogstraten
Aug 26, 1998·Stroke; a Journal of Cerebral Circulation·H M FinlayP B Canham
Sep 15, 1998·Kidney International. Supplement·B J BallermannA Liu
Nov 3, 1998·Cardiovascular Research·S K SamijoA P Hoeks
Aug 12, 1999·Cellular and Molecular Life Sciences : CMLS·J F ArnalJ Rami
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·H MasudaS Glagov
Oct 16, 1999·Archives of Surgery·S G FrangosB Sumpio
Dec 14, 1999·Nihon rinsho. Japanese journal of clinical medicine·N Yamada

❮ Previous
Next ❯

Citations

Dec 7, 2013·Neurosurgical Review·S BacigaluppiM Fontanella
Dec 18, 2012·Annals of Biomedical Engineering·Juan R Cebral, Marcelo Raschi
Apr 9, 2013·Medical & Biological Engineering & Computing·Woowon JeongKyehan Rhee
Apr 3, 2013·Clinical Neurology and Neurosurgery·Young Dae ChoJeong Wook Lim
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Katsuhito YasunoMurat Günel
May 8, 2013·Cardiovascular Research·Jennifer FruehRob Krams
Mar 29, 2012·Computational and Mathematical Methods in Medicine·Woowon Jeong, Kyehan Rhee
Jul 14, 2012·Neurosurgical Review·Marcio L Tostes dos SantosWaldir Antônio Tognola
Nov 26, 2014·Surgical Neurology International·Pablo M MunarrizAlfonso Lagares
Nov 6, 2010·AJNR. American Journal of Neuroradiology·J R CebralC M Putman
Jan 12, 2013·AJNR. American Journal of Neuroradiology·F GrazianoA J Ulm
Jun 5, 2013·Neurocirugía·Ana M Castaño-LeonAlfonso Lagares
Jul 29, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·George K C Wong, W S Poon
Apr 16, 2011·World Neurosurgery·Bernard R Bendok, Rudy J Rahme
Apr 17, 2016·Journal of the Neurological Sciences·Wei-Hua WangDong Guo
Jul 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nohra ChalouhiAaron S Dumont
May 10, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Jong S Kim, Youngshin Yoon
Sep 21, 2013·IEEE Transactions on Visualization and Computer Graphics·Benjamin KöhlerBernhard Preim
Oct 29, 2011·IEEE Transactions on Visualization and Computer Graphics·Rocco GasteigerBernhard Preim
Apr 26, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Ali Sarrami-ForoushaniHossein Ghanaati
Jan 26, 2016·World Neurosurgery·Pablo M MunarrizAlfonso Lagares
Apr 26, 2013·Neurologia Medico-chirurgica·Tetsuo SasakiShigeaki Kobayashi
Jan 15, 2013·Mediators of Inflammation·Nohra ChalouhiAaron S Dumont
Jan 26, 2013·European Journal of Radiology·Vitor Mendes PereiraLovblad Karl-Olof
Oct 26, 2010·Atherosclerosis·Emanuele CecchiLucia Mannini
Aug 10, 2013·Journal of Neurointerventional Surgery·Alexandra LauricAdel M Malek
Jul 22, 2016·Biomechanics and Modeling in Mechanobiology·A J GeersA F Frangi
Aug 2, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·James A LeeJonathan Golledge
Aug 10, 2016·Frontiers in Surgery·Vernard S FennellRobert F Spetzler

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
ISAs

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.