PMID: 12763130May 24, 2003Paper

The critical role of perinatal pathology

BJOG : an International Journal of Obstetrics and Gynaecology
Iona J M Jeffrey

Abstract

In spite of great advances in imaging and biochemistry, histological examination of tissues remains a vital part of the multidisciplinary approach to the prevention of the onset, morbidity and mortality of preterm birth. There has been increasing interest in the role of infection and inflammatory cytokines in causation both of early labour and the white matter damage in the brain of preterm infants. However, labour itself is associated with the build up of increased numbers of inflammatory cells in the uterine cervix and increased concentrations of inflammatory cytokines and positive microbiological cultures may reflect carriage or contamination. Confirmation of an infective aetiology in an individual case is best achieved by demonstration of a pathological inflammatory response in tissues, for example, by showing the presence of chorioamnionitis in the placenta. A proper understanding of the poor response to neonatal intensive care of some preterm babies often requires histological examination of the lungs after death, where unsuspected pneumonia, interstitial emphysema and/or pulmonary hypoplasia may help provide an explanation for the adverse outcome in individual cases. The pathophysiological mechanism of brain injury in pr...Continue Reading

References

Oct 1, 1991·American Journal of Obstetrics and Gynecology·C M SalafiaL Silberman

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Citations

Apr 4, 2006·Biology of the Neonate·Rodolfo BracciGiuseppe Buonocore
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Claudio De FeliceRobert J Kopotic
Dec 8, 2006·Archives of Pathology & Laboratory Medicine·Roberto N MirandaEmad Kaabipour

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