The Croonian Lecture, 1980. The complex proteases of the complement system

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
R R Porter

Abstract

The assembly and activation of the early components of complement, after their interaction with antibody-antigen complexes, are described in terms of the structures of the different proteins taking part. C1q, a molecule of unique half collagen--half globular structure, binds to the second constant domain of the antibody molecules through its six globular heads. A tetrameric complex of C1r2-C1s2 binds to the collagenous tails and leads to formation of the serine-type proteases C1r and C1s. C1s activates C4, which forms a covalent bond between its alpha' chain and the Fab section of the antibody. C2 is also activated by C1s and associates with the bound C4 molecule to form C42, a labile protease that activates C3, but which loses activity as the C2 peptide chains dissociate from C4. C2, by analogy with factor B, the equivalent component of the alternative pathway of activation, appears to be a novel type of serine protease with a similar catalytic site but different activation mechanism to the serine proteases that have been described previously.

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Citations

Jan 1, 1983·Molecular Aspects of Medicine·S Elödi, P Elödi
Jan 4, 1982·Biochimica Et Biophysica Acta·C L VilliersM G Colomb
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·G Garratty
Sep 14, 1981·FEBS Letters·M B VilliersM G Colomb
Oct 12, 1981·FEBS Letters·A ReboulM G Colomb
Oct 1, 1985·Immunological Reviews·R D Campbell, D R Bentley
Apr 1, 1996·Tissue Antigens·L LinT Juji
Apr 1, 1994·Tissue Antigens·W H HildebrandP Parham
Sep 6, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M G ColombC L Villiers
Sep 6, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R D CampbellB J Morley
Jan 1, 1984·CRC Critical Reviews in Biochemistry·R R Porter

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