The cross-mammalian neurophenomenology of primal emotional affects: From animal feelings to human therapeutics

The Journal of Comparative Neurology
Jaak Panksepp

Abstract

The neural correlates of human emotions are easy to harvest. In contrast, the neural constitution of emotional feelings in humans has resisted systematic scientific analysis. This review summarizes how preclinical affective neuroscience initiatives are making progress in decoding the neural nature of such feelings in animal brains. This has been achieved by studying the rewarding and punishing effects of deep brain stimulation (DBS) of subcortical emotional networks (labeled SEEING, RAGE, FEAR, LUST, CARE, PANIC, and PLAY systems) that evoke distinct emotion action patterns, as well as rewarding and punishing effects in animals. The implications of this knowledge for development of new psychiatric interventions, especially depression, are discussed. Three new antidepressive therapeutics arising from this work are briefly noted: 1) DBS of the medial forebrain bundle (MFB) in humans, 2) reduction of psychological pain that may arise from excessive PANIC arousal, and 3) facilitation of social joy through the study of social play in rats The overall argument is that we may more readily develop new psychiatric interventions through preclinical models if we take animal emotional feelings seriously, as opposed to just behavioral chang...Continue Reading

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Citations

Jul 8, 2020·Scientific Reports·Sharon A StevensonLauren V Riters
Jul 1, 2020·Frontiers in Psychology·Todd E Feinberg, Jon Mallatt
Apr 27, 2017·Frontiers in Psychology·Christian Montag, Jaak Panksepp
Apr 30, 2019·Frontiers in Physiology·Lauren V RitersJeremy A Spool
Jul 25, 2019·Neuroscience and Biobehavioral Reviews·Lily R AleksandrovaAnthony G Phillips
Feb 1, 2020·Neuroscience and Biobehavioral Reviews·Juan A AriasAndrew H Kemp
Jan 27, 2020·Neuroscience and Biobehavioral Reviews·L KremerL E Webb

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