The cross-priming APC requires a Rel-dependent signal to induce CTL

The Journal of Immunology : Official Journal of the American Association of Immunologists
Justine D MinternW R Heath

Abstract

Induction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40.

References

Feb 1, 1990·The Journal of Experimental Medicine·F R Carbone, M J Bevan
Mar 1, 1990·Nature·J Nikolić-Zugić, M J Bevan
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
May 2, 1994·Journal of Immunological Methods·A B Lyons, C R Parish
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·S GerondakisR J Grumont
Sep 1, 1996·The Journal of Experimental Medicine·C KurtsH Kosaka
Jul 7, 1997·The Journal of Experimental Medicine·S R BennettW R Heath
Feb 7, 1998·The Journal of Experimental Medicine·W C Sha
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Aug 26, 1998·Immunology Today·F R CarboneW R Heath
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OhashiH Kolb
Jan 19, 2000·The Journal of Experimental Medicine·N GarceauR J Noelle
Jun 3, 2000·Annual Review of Immunology·F SallustoA Lanzavecchia
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
Dec 29, 2000·Nature·H HemmiS Akira
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H HochreinM O'Keeffe
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justine D MinternWilliam R Heath

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Citations

Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie E BlachèreMatthew L Albert
Jul 1, 2006·European Journal of Immunology·Agne Le BonPersephone Borrow
Mar 1, 2007·Cytometry. Part B, Clinical Cytometry·Arancha Rodriguez-CaballeroAlberto Orfao
Dec 2, 2009·European Journal of Immunology·Elissa K DeenickPamela S Ohashi
Dec 2, 2010·International Immunology·Kimberly A JordanChristopher A Hunter
Sep 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·E AndreakosM Feldmann
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jagadeesh BayrySrini V Kaveri
Jul 6, 2004·Immunological Reviews·William R HeathJose A Villadangos
Dec 10, 2009·The Journal of Experimental Medicine·Iwao IsomuraSteve Gerondakis

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