The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Frontiers in Microbiology
Dapeng ZhangYibin Feng

Abstract

Emerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut-lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as well as the disease development in the lungs. In this article, we systemically review the role and mechanisms underlying the changes in the constituent of gut microbiota and metabolites in lung diseases. In particular, the roles of gut-lung axis in mediating immune responses and reshaping inflammation are highlighted. Furthermore, we discuss the potential of strategies to manipulate the gut microbiota and metabolites as the therapeutic approach for lung diseases.

References

Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Tricia M McKeeverRichard Hubbard
May 16, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akihito InatsuShuhji Seki
Feb 23, 2010·American Journal of Epidemiology·Raphaëlle VarrasoCarlos A Camargo
Feb 5, 2011·Seminars in Immunology·Jan KranichCharles R Mackay
Feb 16, 2011·Archives of Internal Medicine·Yikyung ParkArthur Schatzkin
Jun 18, 2011·American Journal of Respiratory and Critical Care Medicine·Emily S CharlsonRonald G Collman
Nov 18, 2011·Mucosal Immunology·S KeelyP M Hansbro
Feb 10, 2012·Nature·Steven Z JosefowiczAlexander Y Rudensky
Nov 16, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Gwen DuytschaeverPeter Vandamme
Jun 6, 2013·Mediators of Inflammation·Esmaeil MortazJohan Garssen
Jul 3, 2013·Cold Spring Harbor Perspectives in Medicine·Birgitta Henriques-Normark, Elaine I Tuomanen
Jul 4, 2013·Médecine et maladies infectieuses·Y AlexandreR Le Berre
Sep 21, 2013·Nature Immunology·Craig N Jenne, Paul Kubes
Dec 18, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T R AbrahamssonM C Jenmalm
Jan 1, 2014·World Journal of Gastroenterology : WJG·Adriana HaackMaria Rita Carvalho Garbi Novaes
Apr 1, 2014·Cell·Yasmine Belkaid, Timothy W Hand
Apr 29, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Li Li, Shawn Somerset
May 23, 2014·The New England Journal of Medicine·Gail M GauvreauJane R Parnes
Jan 13, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·William P SexauerAllison M Mallowe
Feb 7, 2015·Pediatric Pulmonology·Michelle B VanstoneThomas O Carpenter
May 12, 2015·Journal of Immunotherapy·Félix AragónAlejandra de Moreno de LeBlanc
Jul 1, 2015·Genetics and Molecular Research : GMR·Q-F GuiY-H Yang
Jul 29, 2015·Infection and Immunity·Stefanie GauguetGerald B Pier
Sep 4, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Griet DebyserBart Devreese
Oct 17, 2015·American Journal of Respiratory Cell and Molecular Biology·Robert P YoungBenjamin Marsland
Nov 7, 2015·Science·Marie VétizouLaurence Zitvogel
Nov 10, 2015·Journal of Pediatric Gastroenterology and Nutrition·Robert C De Lisle
Nov 26, 2015·Annals of the American Thoracic Society·Benjamin J MarslandEva S Gollwitzer
Feb 10, 2016·Clinics in Chest Medicine·Yvonne J Huang, John J LiPuma
Apr 30, 2016·Science·Thomas GensollenRichard S Blumberg

❮ Previous
Next ❯

Citations

May 15, 2020·Genes·Alice Françoise, Geneviève Héry-Arnaud
Jul 9, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Qing YeShiqiang Shang
Sep 24, 2020·Biomedicines·Mª Amelia Gomez-LlorenteCarolina Gomez-Llorente
Aug 28, 2020·International Journal of Molecular Sciences·Josep Mercader-BarcelóAlice Chaplin
Oct 7, 2020·Biology·Luigi SantacroceSkender Topi
Nov 28, 2020·Microbial Cell Factories·Taha BaghbaniHamed Haddad Kashani
Dec 22, 2020·Trends in Endocrinology and Metabolism : TEM·Michael BlatzerJean-Paul Latgé
Jan 27, 2021·Indian Journal of Clinical Biochemistry : IJCB·Swati RajputSatyavati Rana
Oct 17, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Veronica OjettiUNKNOWN GEMELLI AGAINST COVID‐19 group
Oct 21, 2020·Journal of Bacteriology·An ZhouBo Tang
Dec 17, 2020·Frontiers in Cellular and Infection Microbiology·Sabrina Donati ZeppaPiero Sestili
Jan 31, 2021·Life·Filippo ScialoGiuseppe Castaldo
Feb 16, 2021·Frontiers in Cellular and Infection Microbiology·Elisavet StavropoulouEugenia Bezirtzoglou
Feb 18, 2021·PloS One·Antonio MazzarelliUNKNOWN INMI COVID-19 study group
Feb 2, 2021·Trends in Food Science & Technology·Jielun HuSiew C Ng
Mar 7, 2021·Metabolites·Aravind ThavamaniSenthilkumar Sankararaman
Mar 9, 2021·Frontiers in Medicine·Christian A DevauxDidier Raoult
Jan 5, 2021·Journal of Pediatric Gastroenterology and Nutrition·Racha T KhalafJ Kirk Harris
Mar 16, 2021·Frontiers in Immunology·Gislane Lelis Vilela de OliveiraCristina Ribeiro de Barros Cardoso
Mar 27, 2021·Probiotics and Antimicrobial Proteins·Shima Moradi-KalbolandiLeila Farahmand
Apr 4, 2021·International Journal of Molecular Sciences·Negin KazemianSepideh Pakpour
Apr 3, 2021·Frontiers in Medicine·Ella BurchillNikhil Sharma
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Indranil Chattopadhyay, Esaki M Shankar
Jan 28, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Meli'sa S CrawfordDeclan F McCole
Apr 13, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Amin GasmiGeir Bjørklund
May 1, 2021·Biomedicines·Paschalis NtoliosPaschalis Steiropoulos
May 1, 2021·Microorganisms·Thomas GautierLatifa Bousarghin
May 11, 2021·World Journal of Gastroenterology : WJG·Mohammed Al-BeltagiYasser El-Sawaf
Jun 3, 2021·Nutrients·Christophe Espírito SantoInês Brandão
Jun 13, 2021·Autoimmunity Reviews·Nurit Katz-Agranov, Gisele Zandman-Goddard
Jul 9, 2021·Frontiers in Microbiology·Dominika Jakubczyk, Sabina Górska
Jun 17, 2021·International Journal of Clinical Practice·Yen-Chu HuangJames Cheng-Chung Wei
Aug 3, 2021·Frontiers in Microbiology·Shukai ZhanZhirong Zeng
May 20, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Emile LevySchohraya Spahis

❮ Previous
Next ❯

Software Mentioned

Dialister

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Frontiers in Microbiology
Swadha Anand, Sharmila S Mande
Nature Reviews. Microbiology
Kurtis F BuddenPhilip M Hansbro
Science China. Life Sciences
Jian WangZhigang Tian
© 2021 Meta ULC. All rights reserved